Exact conditional maximized sequential probability ratio test adjusted for covariates.

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dc.contributor.authorSilva, Ivair Ramos
dc.contributor.authorLingling, Li
dc.contributor.authorKulldorff, Martin
dc.date.accessioned2020-08-17T14:07:00Z
dc.date.available2020-08-17T14:07:00Z
dc.date.issued2019
dc.description.abstractSequential analysis is now commonly used for post-market drug and vaccine safety surveillance, and a Poisson stochastic process is typically used for rare adverse events. The conditional maximized sequential probability ratio test, CMaxSPRT, is a powerful tool when there is uncertainty in the estimated expected counts under the null hypothesis. This paper derives exact critical values for CMaxSPRT, as well as statistical power and expected time to signal. This is done for both continuous and group sequential analysis, and for different rejection boundaries. It is also shown how to adjust for covariates in the sequential design. A table of critical values is provided for selected parameters and rejection boundaries, while new functions in the R Sequential package can be used for other calculations. In addition, the method is illustrated for monitoring adverse events after pediarix vaccination data.pt_BR
dc.identifier.citationSILVA, I. R.; LINGLING, L.; KULLDORFF, M. Exact conditional maximized sequential probability ratio test adjusted for covariates. Sequential Analysis-Design Methods and Applications, v. 38, n. 1, p. 115-133, maio 2019. Disponível em: <https://www.tandfonline.com/doi/abs/10.1080/07474946.2019.1574446?journalCode=lsqa20>. Acesso em: 03 jul. 2020.pt_BR
dc.identifier.doihttps://doi.org/10.1080/07474946.2019.1574446pt_BR
dc.identifier.issn1532-4176
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/12604
dc.identifier.uri2https://www.tandfonline.com/doi/abs/10.1080/07474946.2019.1574446?journalCode=lsqa20pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectMaximized sequential probability ratio test (MaxSPRT)pt_BR
dc.subjectPoisson distributionpt_BR
dc.subjectType I error spendingpt_BR
dc.titleExact conditional maximized sequential probability ratio test adjusted for covariates.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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