Anti-mycobacterium tuberculosis and cytotoxicity activities of Ruthenium(II)/ bipyridine/diphosphine/pyrimidine-2-thiolate complexes : the role of the non- coordinated N-atom.

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dc.contributor.authorBenedicto, Augusto Vieira Lima
dc.contributor.authorCorrea, Rodrigo de Souza
dc.contributor.authorGraminha, Angelica Ellen
dc.contributor.authorKuznetsov, Aleksey Evgenyevich
dc.contributor.authorEllena, Javier Alcides
dc.contributor.authorPavan, Fernando Rogério
dc.contributor.authorLeite, Clarice Queico Fujimura
dc.contributor.authorBatista, Alzir Azevedo
dc.date.accessioned2016-11-07T13:17:27Z
dc.date.available2016-11-07T13:17:27Z
dc.date.issued2016
dc.description.abstractThe [Ru(Spym)(bipy)(P–P)]PF6, [Spym = pyrimidine-2-thiolate anion; P–P = 1,2-bis(diphenylphosphino)ethane, 1,3-bis(diphenylphosphino)propane and 1,1’-bis(diphenylphosphino)ferrocene] complexes were synthesized and characterized by spectroscopic, electrochemical and elemental analysis, and by X-ray crystallography. The minimal inhibitory concentration (MIC) of the compounds against Mycobacterium tuberculosis and the complex concentration causing 50% tumor cell growth inhibition (IC50) against breast cancer cells, MDA-MB-231, were determined. All three compounds gave promising values in both tests. It is interesting to mention that all three complexes display MICs against Mycobacterium tuberculosis showing higher activity than cycloserine, a second line drug used in the treatment of the illness. The complexes interact weakly with the DNA.pt_BR
dc.identifier.citationBENEDICTO, A. V. L. et al. Anti-mycobacterium tuberculosis and cytotoxicity activities of Ruthenium(II)/ bipyridine/diphosphine/pyrimidine-2-thiolate complexes: the role of the non-coordinated N-atom. Journal of the Brazilian Chemical Society, v. 27, p. 30-40, 2016. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000100030>. Acesso em: 26 set. 2016.pt_BR
dc.identifier.doihttp://dx.doi.org/10.5935/0103-5053.20150237
dc.identifier.issn1678-4790
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/7066
dc.language.isoen_USpt_BR
dc.rightsabertopt_BR
dc.rights.licenseTodo o conteúdo do periódico Journal of the Brazilian Chemical Society, exceto onde identificado, está sob uma licença Creative Commons 4.0 que permite copiar, distribuir e transmitir o trabalho em qualquer suporte ou formato desde que sejam citados o autor e o licenciante. Não permite o uso para fins comerciais. Fonte: Journal of the Brazilian Chemical Society <http://www.scielo.br/scielo.php?script=sci_serial&pid=0103-5053&lng=en&nrm=iso>. Acesso em: 23 ago. 2019.pt_BR
dc.subjectRuthenium complexespt_BR
dc.subjectPyrimidine-2-thiolatept_BR
dc.subjectDiphosphine ligandpt_BR
dc.subjectCytotoxity - tuberculosispt_BR
dc.titleAnti-mycobacterium tuberculosis and cytotoxicity activities of Ruthenium(II)/ bipyridine/diphosphine/pyrimidine-2-thiolate complexes : the role of the non- coordinated N-atom.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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