Lycopene mitigates pulmonary emphysema induced by cigarette smoke in a murine model.
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Date
2019
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Abstract
Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease characterized by a non-fully reversible airflow limitation comprising chronic
bronchitis and pulmonary emphysema both being induced by cigarette smoke (CS) exposure. Lycopene has shown antioxidant and anti-inflammatory properties
that can prevent acute lung inflammation and emphysema. We hypothesized that administration with lycopene would repair lung damage in emphysema
caused by CS exposure. Mice were administered with two different doses of lycopene (25 or 50 mg/kg/day, diluted in sunflower oil by orogastric gavage) and
then exposed to 60 days of CS or not (CG). Lycopene promoted a reduction in the number of total leukocytes and it improved pulmonary emphysema. Lycopene
was able to minimize redox processes by decreasing lipid peroxidation and DNA damage, and by having an increase in the activities of SOD, CAT and GSH
content. Furthermore, it decreased levels of TNF-α, IFN-γ and IL-10. In addition, it was able to decrease MPO activity and nitrite content. In conclusion, our data
elucidated the role of lycopene as an antioxidant and anti-inflammatory agent in mice exposed to CS.
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Keywords
Inflammation, Chronic obstructive pulmonary disease, Mice
Citation
CAMPOS, K. K. D. et al. Lycopene mitigates pulmonary emphysema induced by cigarette smoke in a murine model. The Journal of Nutritional Biochemistry, v. 65, p. 93-100, mar. 2019. Disponível em: <https://www.sciencedirect.com/science/article/pii/S095528631830158X>. Acesso em: 22 fev. 2019.