Evidence for a role of ACTN3 R577X polymorphism in football player’s career progression.
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Date
2018
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Abstract
The aim was to investigate a possible role of the ACTN3 R577X
polymorphism in a Brazilian football player’s career progression. 2 questions were formulated: 1. Does ACTN3 polymorphism affect the probability of an individual being a professional football player? 2. Does this polymorphism affect the
progression of the athlete throughout his career? The study
included 353 players from first division Brazilian football clubs
in the following categories: under-14 (U-14), U-15, U-17, U-20,
and professional (PRO). The control group (CON) was composed of 100 healthy non-athletes. The chi-squared test was
used to assess differences between the allele and genotype
frequencies. Comparing football categories, the XX genotype
was less frequent among professional players than in the U-20
(p<0.05) or the U-15 category (p<0.05). The RX genotype also
presented more frequently in the PRO category than the U-14
category (p < 0.05). Moreover, a trend towards a higher frequency of the RX genotype and a lower frequency of the XX
genotype was observed in the professional category compared
to U-20. These results suggest that the genotype in the ACTN3
polymorphism affects the probability of a football player progressing throughout his career and becoming professional,
meaning that playing football selects against the ACTN3 XX
genotype.
Description
Keywords
Alpha-actinin-3, Allele distribution, Genotypic distribution
Citation
COELHO, D. B. et al. Evidence for a role of ACTN3 R577X polymorphism in football player’s career progression. International Journal of Sports Medicine, v. 34, n. 14, p. 1088-1093, 2018. Disponível em: <https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-0753-4973>. Acesso em: 20 fev. 2019.