The role of dorsomedial hypotalamus ionotropic glutamate receptors in the hypertensive and tachycardic responses evoked by Tityustoxin intracerebroventricular injection.

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dc.contributor.authorSilva, Fernanda Cacilda dos Santos
dc.contributor.authorGuidine, Patrícia Alves Maia
dc.contributor.authorMachado, Natália Lima Santos
dc.contributor.authorXavier, Carlos Henrique
dc.contributor.authorMenezes, Rodrigo Cunha Alvim de
dc.contributor.authorSantos, Tasso Moraes
dc.contributor.authorMoraes, Márcio Flávio Dutra
dc.contributor.authorChianca Júnior, Deoclécio Alves
dc.date.accessioned2016-01-18T16:39:53Z
dc.date.available2016-01-18T16:39:53Z
dc.date.issued2015
dc.description.abstractThe scorpion envenoming syndrome is an important worldwide public health problem due to its high incidence and potential severity of symptoms. Some studies address the high sensitivity of the central nervous system to this toxin action. It is known that cardiorespiratory manifestations involve the activation of the autonomic nervous system. However, the origin of this modulation remains unclear. Considering the important participation of the dorsomedial hypotalamus (DMH) in the cardiovascular responses during emergencial situations, the aim of this work is to investigate the involvement of the DMH on cardiovascular responses induced by intracerebroventricular (icv) injection of Tityustoxin (TsTX, a a-type toxin extracted from the Tityus serrulatus scorpion venom). Urethane-anaesthetized male Wistar rats (n = 30) were treated with PBS, muscimol or ionotropic glutamate receptor antagonists, bilaterally in DMH and later, with an icv injection of TsTX, or treated only with PBS in both regions. TsTX evoked a marked increase in mean arterial pressure and heart rate in all control rats. Interestingly, injection of muscimol, a GABAA receptor agonist, did not change the pressor and tachycardic responses evoked by TsTX. Remarkably, the injection ionotropic glutamate receptors antagonists in DMH abolished the pressor and the tachycardic response evoked by TsTX. Our data suggest that the central circuit recruited by TsTX, whose activation results in an array of physiological and behavioral alterations, depend on the activation of DMH ionotropic glutamate receptors. Moreover, our data provide new insights on the central mechanisms involved in the development of symptoms in the severe scorpion envenomation syndromept_BR
dc.identifier.citationSILVA, F. C. dos S. et al. The role of dorsomedial hypotalamus ionotropic glutamate receptors in the hypertensive and tachycardic responses evoked by Tityustoxin intracerebroventricular injection. Neurotoxicology, v. 47, p. 54-61, 2015. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0161813X14002216>. Acesso em: 15 out. 2015.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.neuro.2014.12.006
dc.identifier.issn0161-813X
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/6117
dc.language.isoen_USpt_BR
dc.rights.licenseO periódico NeuroToxicology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3732991138094.pt_BR
dc.subjectScorpion envenomationpt_BR
dc.subjectTityustoxinpt_BR
dc.subjectDorsomedial hypothalamuspt_BR
dc.subjectIonotropic glutamate receptorpt_BR
dc.subjectCardiovascular responsespt_BR
dc.titleThe role of dorsomedial hypotalamus ionotropic glutamate receptors in the hypertensive and tachycardic responses evoked by Tityustoxin intracerebroventricular injection.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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