Clinical aspects of Chagas disease and implications for novel therapies.

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dc.contributor.authorMenezes, Cristiane Alves da Silva
dc.contributor.authorCosta, Germano Carneiro
dc.contributor.authorGollob, Kenneth John
dc.contributor.authorDutra, Walderez Ornelas
dc.date.accessioned2017-06-05T16:42:54Z
dc.date.available2017-06-05T16:42:54Z
dc.date.issued2011
dc.description.abstractThe interaction between the protozoan parasite Trypanosoma cruzi and the human host dates back 9,000 years, as demonstrated by molecular analysis of material obtained from Andean mummies indicating the presence of the parasite’s kinetoplast DNA in populations from Chile and Peru. This long-established interaction, which persists today, demonstrates that T. cruzi has established a very well adapted relationship with the human host. From the point of view of a host–parasite relationship, this is desirable; however, such a high degree of adaptation is perhaps the foundation for many of the unknowns that surround this disease. Unveiling of the immunological mechanisms that underlie the establishment of pathology, identification of parasite-associated factors that determine strain-differential tissue tropism, discovery of host genetic elements that influence the development of different clinical forms of the disease, and understanding environmental factors that may influence the host–parasite interactions are some of the key questions that remain to be answered. The response to these questions will aid in addressing some of the current challenges in Chagas disease: fulfilling the need for efficient diagnosis, developing effective prophylactic measures, discovering effective therapeutics, and finding methods to control disease progression.pt_BR
dc.identifier.citationMENEZES, C. A. da S. et al. Clinical aspects of Chagas disease and implications for novel therapies. Drug Developmental Research, v. 72, p. 471-479, 2011. Disponível em: <https://goo.gl/xh0SgH>. Acesso em: 19 fev. 2017.pt_BR
dc.identifier.doihttps://doi.org/10.1002/ddr.20454
dc.identifier.issn1098-2299
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/7881
dc.identifier.uri2https://goo.gl/xh0SgHpt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectPathologypt_BR
dc.subjectCardiomyopathypt_BR
dc.subjectTreatmentpt_BR
dc.subjectTrypanosoma cruzipt_BR
dc.titleClinical aspects of Chagas disease and implications for novel therapies.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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