Molecular and biological characterization of Trypanosoma cruzi strains isolated from children from Jequitinhonha Valley, State of Minas Gerais, Brazil.

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dc.contributor.authorSilva, Jaquelline Carla Valamiel de Oliveira e
dc.contributor.authorAssis, Girley Francisco Machado de
dc.contributor.authorOliveira, Maykon Tavares de
dc.contributor.authorValadares, Helder Magno Silva
dc.contributor.authorValle, Ítalo Faria do
dc.contributor.authorPaiva, Nívia Carolina Nogueira de
dc.contributor.authorMartins, Helen Rodrigues
dc.contributor.authorLana, Marta de
dc.date.accessioned2014-11-20T15:48:44Z
dc.date.available2014-11-20T15:48:44Z
dc.date.issued2013
dc.description.abstractThe biological diversity of Trypanosoma cruzi strains plays an important role in the clinical and epidemiological features of Chagas disease. Methods: Eight T. cruzi strains isolated from children living in a Chagas disease vector-controlled area of Jequitinhonha Valley, State of Minas Gerais, Brazil, were genetically and biologically characterized. Results: The characterizations demonstrated that all of the strains belonged to T. cruzi II, and showed high infectivity and a variable mean maximum peak of parasitemia. Six strains displayed low parasitemia, and two displayed moderate parasitemia. Later peaks of parasitemia and a predominance of intermediate and large trypomastigotes in all T. cruzi strains were observed. The mean prepatent period was relatively short (4.2±0.25 to 13.7±3.08 days), whereas the patent period ranged from 3.3±1.08 to 34.5±3.52 days. Mortality was observed only in animals infected with strain 806 (62.5%). Histopathological analysis of the heart showed that strains 501 and 806 caused infl ammation, but fi brosis was observed only in animals infected with strain 806. Conclusions: The results indicate the presence of an association between the biological behavior in mice and the genetic characteristics of the parasites. The study also confi rmed general data from Brazil where T. cruzi II lineage is the most prevalent in the domiciliary cycle and generally has low virulence, with some strains capable of inducing infl ammatory processes and fi brosis.pt_BR
dc.identifier.citationSILVA, J. C. V. de O. e et al. Molecular and biological characterization of Trypanosoma cruzi strains isolated from children from Jequitinhonha Valley, State of Minas Gerais, Brazil. Revista da Sociedade Brasileira de Medicina Tropical v. 46, p. 433-440, 2013. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000400433&lng=en&nrm=iso&tlng=en>. Acesso em: 20 ago. 2014.pt_BR
dc.identifier.doihttp://dx.doi.org/10.1590/0037-8682-0077-2013
dc.identifier.issn0037-8682
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/3998
dc.language.isoen_USpt_BR
dc.rights.licenseA Revista da Sociedade Brasileira de Medicina Tropical permite o depósito das versões pré-print e pós-print de um artigo. Permite remixagem, adaptação e nova criação a partir da obra para fins não comerciais desde que seja atribuído o crédito ao autor (CC BY-NC). Fonte: Diadorim <http://diadorim.ibict.br/handle/1/127>. Acesso em: 10 fev. 2020.pt_BR
dc.subjectTrypanosoma cruzi strainspt_BR
dc.subjectJequitinhonha Valleypt_BR
dc.subjectMolecular characterizationpt_BR
dc.subjectBiological characterizationpt_BR
dc.titleMolecular and biological characterization of Trypanosoma cruzi strains isolated from children from Jequitinhonha Valley, State of Minas Gerais, Brazil.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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