Ru(II)–thyminate complexes : new metallodrug candidates against tumor cells.
| dc.contributor.author | Correa, Rodrigo de Souza | |
| dc.contributor.author | Freire, Vitória | |
| dc.contributor.author | Barbosa, Marília Imaculada Frazão | |
| dc.contributor.author | Bezerra, Daniel Pereira | |
| dc.contributor.author | Bomfim, Larissa Mendes | |
| dc.contributor.author | Moreira, Diogo Rodrigo de Magalhães | |
| dc.contributor.author | Soares, Milena Botelho Pereira | |
| dc.contributor.author | Ellena, Javier Alcides | |
| dc.contributor.author | Batista, Alzir Azevedo | |
| dc.date.accessioned | 2019-05-08T15:41:41Z | |
| dc.date.available | 2019-05-08T15:41:41Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | Herein, we used thymine (HThy) as a ligand to form two new ruthenium(II) complexes with formula [Ru(PPh3)2(Thy)(bipy)]PF6 (1) and [Ru(Thy)(bipy)(dppb)]PF6 (2). The complexes were characterized by spectroscopic, spectrometric and X-ray crystallography analyses. Complexes 1 and 2 can interact with ctDNA presenting binding constants, Kb, of 0.4 and 1.2 × 103 M−1, respectively. Their cytotoxic activities towards tumor cell lines (B16-F10, HepG2, K562 and HL-60) and non-tumor cells (PBMCs) were evaluated using the Alamar blue assay. Complex 1 exhibits high cytotoxicity against tumor cells, showing IC50 values of 0.01 and 1.81 μM against the HL-60 and HepG2 cell lines, respectively. Therefore, compound 1 can be considered as a promising antitumor metallodrug. | pt_BR |
| dc.identifier.citation | CORREA, R. de S. et al. Ru(II)–thyminate complexes : new metallodrug candidates against tumor cells. New Journal of Chemistry, v. 42, p. 6794--6802, 2018. Disponível em: <https://pubs.rsc.org/en/content/articlelanding/2018/nj/c7nj04368f#!divAbstract>. Acesso em: 7 mar. 2019. | pt_BR |
| dc.identifier.doi | http://doi.org/10.1039/c7nj04368f | pt_BR |
| dc.identifier.issn | 1369-9261 | |
| dc.identifier.uri | http://www.repositorio.ufop.br/handle/123456789/11226 | |
| dc.identifier.uri2 | https://pubs.rsc.org/en/content/articlelanding/2018/NJ/C7NJ04368F#!divAbstract | pt_BR |
| dc.language.iso | en_US | pt_BR |
| dc.rights | restrito | pt_BR |
| dc.title | Ru(II)–thyminate complexes : new metallodrug candidates against tumor cells. | pt_BR |
| dc.type | Artigo publicado em periodico | pt_BR |