The administration of surfactant decreased oxidative stress in lungs of mice exposed to cigarette smoke.
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Date
2018
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Abstract
The alveolar surfactant, which composition consists of a unique and complex mixture of lipids and proteins, has
immunomodulatory action. This study aimed to evaluate the effects of exogenous surfactant on pulmonary
inflammatory response in mice exposed to cigarette smoke (CS). Twenty-four mice C57BL/6 were divided into
four groups: control group exposed to ambient air (CG); surfactant treated group (SG); CS exposed group (CSG)
and CS exposed group treated with surfactant (CSSG). For five days, CSG and CSSG were exposed to 12 commercial
cigarettes/day and SG and CSSG received the surfactant by intranasal instillation. At the end of the
experiment, the animals were euthanatized for the collection of bronchoalveolar lavage fluid (BALF) and lungs.
The total number of leukocytes in BALF increased in CSG compared to CG, however, there was a decrease in
CSSG compared to CSG. There was an increase in lipid peroxidation in SG and CSG compared to CG while there
was a decrease in CSSG compared to CSG. Regarding the antioxidant enzymes, the catalase (CAT) activity
increased in all groups compared to CG and the superoxide dismutase (SOD) activity decreased in CSG compared
to the CG and SG. There was an increase in TNF in SG, CSG and CSSG compared to CG. There was an increase in
IL-17 in CSSG compared to CG. There was an increase in CCL5 in SG and CSSG compared to CG. Therefore, our
results demonstrated that the administration of exogenous surfactant was able to decrease the oxidative processes
in the lungs of mice induced by short-term exposure to CS.
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Keywords
Cigarette smoke, Lung inflammation, Redox imbalance, Exogeneous surfactant
Citation
MACHADO, D. F. et al. The administration of surfactant decreased oxidative stress in lungs of mice exposed to cigarette smoke. International Immunopharmacology, v. 54, p. 275-279, 2018. Disponível em: <https://www.sciencedirect.com/science/article/pii/S1567576917304435?via%3Dihub>. Acesso em: 05 abr. 2018.