cis-bis(N-benzoyl-N0 ,N0 -dibenzylthioureido) platinum(II) : synthesis, molecular structure and its interaction with human and bovine serum albumin.
| dc.contributor.author | Correa, Rodrigo de Souza | |
| dc.contributor.author | Oliveira, Katia Mara de | |
| dc.contributor.author | Pérez, Hiram | |
| dc.contributor.author | Stevens, Ana María Plutín | |
| dc.contributor.author | Ramos Cairo, Raúl | |
| dc.contributor.author | Mocelo, Raúl | |
| dc.contributor.author | Castellano, Eduardo Ernesto | |
| dc.contributor.author | Batista, Alzir Azevedo | |
| dc.date.accessioned | 2020-06-18T16:55:00Z | |
| dc.date.available | 2020-06-18T16:55:00Z | |
| dc.date.issued | 2019 | |
| dc.description.abstract | In this paper, the title compound was synthesized from N-benzoyl-N′,N′-dibenzylthiourea ligand and potassium tetrachloroplatinate(II), and its interaction with human (HSA) and bovine (BSA) serum albumin was evaluated. Also, the crystal structure was determined from single-crystal X‐ray diffraction, confirming that the platinum atom is coordinated with two chelated N-benzoyl-N′,N′-dibenzylthiourea ligands in a distorted square-planar geometry. In the solid state, Hirshfeld surface analysis emphasizes that the molecules are connected by non-classical C–H⋯C, C–H⋯S and H⋯H intermolecular contacts. These weak interactions can be mainly responsible due to complex-BSA and complex-HSA binding. The complex interacts differently with HSA and BSA such as observed by the binding constant, Kb, presenting values of around 105 M−1 and 104 M−1, respectively. Thermodynamic parameters (ΔG, ΔH and ΔS) suggest spontaneous interactions between complex and the proteins. | pt_BR |
| dc.identifier.citation | CORREA, R. S. et al. cis-bis(N-benzoyl-N0 ,N0 -dibenzylthioureido) platinum(II): synthesis, molecular structure and its interaction with human and bovine serum albumin. Arabian Journal of Chemistry, v. 12, n. 8, p. 3454-3462, dez. 2019. Disponível em: <https://www.sciencedirect.com/science/article/pii/S1878535215003020>. Acesso em: 10 fev. 2020. | pt_BR |
| dc.identifier.doi | https://doi.org/10.1016/j.arabjc.2015.10.006 | pt_BR |
| dc.identifier.issn | 1878-5352 | |
| dc.identifier.uri | http://www.repositorio.ufop.br/handle/123456789/12370 | |
| dc.language.iso | en_US | pt_BR |
| dc.rights | aberto | pt_BR |
| dc.rights.license | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/). Fonte: o próprio artigo. | pt_BR |
| dc.subject | Platinum complex | pt_BR |
| dc.subject | Benzoylthiourea | pt_BR |
| dc.subject | Hirshfeld surface | pt_BR |
| dc.title | cis-bis(N-benzoyl-N0 ,N0 -dibenzylthioureido) platinum(II) : synthesis, molecular structure and its interaction with human and bovine serum albumin. | pt_BR |
| dc.type | Artigo publicado em periodico | pt_BR |