Glass-ionomer-propolis composites for caries inhibition: flavonoids release, physical-chemical, antibacterial and mechanical properties.
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Date
2019
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Abstract
The addition of propolis extract (PE) to the glass ionomer results in an adhesive material for restorative
treatment, with interesting properties mainly due to the flavonoids contained in the propolis extract.
However, no study of the flavonoid release profile in these materials was reported. This work studies
the flavonoid release profile in such materials aiming to contribute to the future synthesis of optimized
devices adept to prolong the efficacy of the drug. The study involved the synthesis and study of the
physicochemical, antibacterial and mechanical properties of glass ionomer cement (GIC) and glassionomer-
propolis composites (GIC-PE). The samples were characterized by Fourier transform
infrared spectroscopy, scanning electron microscopy, and thermogravimetric analyses. The released
concentration of flavonoids, the antimicrobial activity and the compressive strength were also
evaluated. Antimicrobial activity was assessed against Streptococcus mutans, Streptococcus salivarius,
and Candida albicans, common pathogens in the mouth. The results indicate that the antibacterial
activity of GIC-PE samples is closely correlated with the release of flavonoids. The method used to
prepare the composite GIC-PE leads to an initial drug delivery burst effect able to diminish partially
the population of bacteria tested. The mechanical properties and thermal stability of GIC-PE are
higher than those of the GIC and are clearly related to its microstructure. This study is clinically
significant because the addition of propolis extract (PE) to the GIC resulted in a novel differentiated
product with enhanced mechanical and antimicrobial properties compared to the GIC.
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Keywords
Drug release, Antibacterial activity
Citation
ANDRADE, A. L. et al. Glass-ionomer-propolis composites for caries inhibition: flavonoids release, physical-chemical, antibacterial and mechanical properties. Biomedical Physics & Engineering Express, v. 5, p. 027006, 2019. Disponível em: <https://iopscience.iop.org/article/10.1088/2057-1976/ab067e>. Acesso em: 19 mar. 2019.