Trypanosoma cruzi : treatment with the iron chelator desferrioxamine reduces parasitemia and mortality in experimentally infected mice.

Simple item page
dc.contributor.authorArantes, Jerusa Marilda
dc.contributor.authorPedrosa, Maria Lúcia
dc.contributor.authorMartins, Helen Rodrigues
dc.contributor.authorVeloso, Vanja Maria
dc.contributor.authorLana, Marta de
dc.contributor.authorBahia, Maria Terezinha
dc.contributor.authorTafuri, Washington Luiz
dc.contributor.authorCarneiro, Cláudia Martins
dc.date.accessioned2012-09-19T15:55:40Z
dc.date.available2012-09-19T15:55:40Z
dc.date.issued2007
dc.description.abstractThe effects of prolonged treatment with iron chelator (desferrioxamine) on the development of infection in mice inoculated with Y Trypanosoma cruzi were determined. Infected/treated mice presented lower levels of parasitemia and reduced mortality rate compared with infected/non-treated animals. The five out of twenty infected/treated mice that survived the acute phase of infection showed negative hemoculture and positive ELISA in the acute and chronic phases and positive PCR in the acute phase: in the chronic phase, three of the animals presented negative PCR. The single surviving infected/non-treated animal exhibited positive hemoculture, PCR and ELISA in both phases of infection. Infected groups presented lower levels of iron in the liver compared with treated/non-infected or non-treated/ non-infected animals. The serum iron levels of the infected/non-treated group were higher on the 21st day post-infection in comparison with control and infected/treated groups. These results suggest that decrease of iron in the host leads to T. cruzi infection attenuation.pt_BR
dc.identifier.citationARANTES, J. M. et al. Trypanosoma cruzi : treatment with the iron chelator desferrioxamine reduces parasitemia and mortality in experimentally infected mice. Experimental Parasitology, v. 117, n. 1, p. 43–50, set. 2007. Disponível em: <https://www.sciencedirect.com/science/article/pii/S001448940700080X>. Acesso em: 19 set. 2012.pt_BR
dc.identifier.issn00144894
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/1406
dc.language.isoen_USpt_BR
dc.rights.licenseO periódico Experimental Parasitology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3281990280591.
dc.titleTrypanosoma cruzi : treatment with the iron chelator desferrioxamine reduces parasitemia and mortality in experimentally infected mice.pt_BR
dc.typeArtigo publicado em periodicopt_BR
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
ARTIGO_TrypanosomaCruziTreatment.pdf
Size:
175.35 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
DEACL - Artigos publicados em periódicos