Açaí (Euterpe oleracea Martius) promotes jejunal tissue regeneration by enhancing antioxidant response in 5-Fluorouracil-Induced mucositis.

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dc.contributor.authorMagalhães, Talita Alves Faria Martins
dc.contributor.authorSouza, Melina Oliveira de
dc.contributor.authorGomes, Sttefany Viana
dc.contributor.authorSilva, Raiana Mendes e
dc.contributor.authorMartins, Flaviano dos Santos
dc.contributor.authorFreitas, Renata Nascimento de
dc.contributor.authorAmaral, Joana Ferreira do
dc.date.accessioned2021-09-18T17:15:17Z
dc.date.available2021-09-18T17:15:17Z
dc.date.issued2020pt_BR
dc.description.abstractIntestinal mucositis (IM) caused by antineoplastic chemotherapy is characterized by an important inflammatory process, which may compromise ongoing treatment. Our study aimed to investigate the effect of Ac¸aı (Euterpe oleracea Martius) on the antioxidant response in BALB/c mice pretreated with Ac¸aı pulp (200 g/kg) for 14 day. A group of animals receiving a single intraperitoneal injection of 5-FU (200 mg/kg) were euthanized on day three (D3) or seven (D7) after administration, the distal jejunum was isolated for the analyses of histology, superoxide dismutase (SOD) and catalase (CAT) enzyme activities, and concentration of total sulfhydryl groups (GSH). Seven days after induction, the intake of Ac¸aı by the IM group almost completely regenerated tissue histology. Notably, SOD activity decreased in the MUC þ Ac¸aı group (D3). CAT activity reduced on D3 and D7 in the IM groups and Ac¸aı treatment groups, respectively. No change was observed in the total GSH concentration at the tissue level. Our results demonstrated the protective effect of Ac¸aı pulp components on intestinal damage induced by 5-FU, as well as the ability to control the response to oxidative stress, in order to mobilize defense pathways and promote tissue repair.pt_BR
dc.identifier.citationMAGALHÃES, T. A. F. M. et al. Açaí (Euterpe oleracea Martius) promotes jejunal tissue regeneration by enhancing antioxidant response in 5-Fluorouracil-Induced mucositis. Nutrition and Cancer, v. 73, n. 3, 2020. Disponível em: <https://www.tandfonline.com/doi/abs/10.1080/01635581.2020.1759659>. Acesso em: 10 jun. 2021.pt_BR
dc.identifier.doihttps://doi.org/10.1080/01635581.2020.1759659pt_BR
dc.identifier.issn1532-7914
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/13756
dc.identifier.uri2https://www.tandfonline.com/doi/abs/10.1080/01635581.2020.1759659pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.titleAçaí (Euterpe oleracea Martius) promotes jejunal tissue regeneration by enhancing antioxidant response in 5-Fluorouracil-Induced mucositis.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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