Cardiopulmonary reflex is attenuated in iron overload conscious rats.

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dc.contributor.authorCardoso, Leonardo Máximo
dc.contributor.authorFernandes, Luciano Gonçalves
dc.contributor.authorAlves, Arthur Moreira
dc.contributor.authorPedrosa, Maria Lúcia
dc.contributor.authorSilva, Marcelo Eustáquio
dc.contributor.authorColombari, Eduardo
dc.contributor.authorMoraes, Márcio Flávio Dutra
dc.contributor.authorChianca Júnior, Deoclécio Alves
dc.date.accessioned2017-06-07T15:53:10Z
dc.date.available2017-06-07T15:53:10Z
dc.date.issued2013
dc.description.abstractIncreased iron intake can lead to iron accumulation in serum and tissues. Its has been described that serum and tissue iron overload increase reactive oxygen species (ROS) levels and reduce the effectiveness of the cardiovascular neural mechanisms involved in the maintenance of the arterial blood pressure whithin a narrow range of variation, therefore, iron overload may disrupt cardiovascular homeostasis contributing to physiopathological status development. In the present study we evaluated whether iron accumulated in serum or tissue of awake animals affect the cardiovascular homeostasis through changes in the cardiopulmonary reflex (CPR). We observed that the CPR is reduced in both serum and tissue iron overloaded groups, but no changes were found in the left ventricular pressure measurements, suggesting that iron-related effects are restrict to the CPR neural pathways.We also observed that the serum overloaded group presented lower basal heart rate levels, suggesting an increased parasympathetic efferent activity directed to the heart in this group. Taken together, our data suggest an important role for the iron-generated ROS to the cardiovascular homeostasis, especially regarding the CPR in awake animals.pt_BR
dc.identifier.citationCARDOSO, L. M. et al. Cardiopulmonary reflex is attenuated in iron overload conscious rats. Nutritional Neuroscience, v. 10, p. 121-128, 2013. Disponível em: <http://www.tandfonline.com/doi/abs/10.1080/10284150701413964>. Acesso em: 19 fev. 2017.pt_BR
dc.identifier.doihttps://doi.org/10.1080/10284150701413964
dc.identifier.issn1476-8305
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/7909
dc.identifier.uri2http://www.tandfonline.com/doi/abs/10.1080/10284150701413964pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectVentricular pressurept_BR
dc.subjectHeart ratept_BR
dc.subjectBlood pressurept_BR
dc.subjectNutritionpt_BR
dc.subjectParasympathetic activitypt_BR
dc.titleCardiopulmonary reflex is attenuated in iron overload conscious rats.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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