New heteroleptic RuII/diphosphine complexes with cytotoxicity against human breast and murine ascitic sarcoma 180 tumor cells.

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dc.contributor.authorLima, Benedicto Augusto Vieira
dc.contributor.authorCorrea, Rodrigo de Souza
dc.contributor.authorGraminha, Angelica Ellen
dc.contributor.authorVarela Júnior, Jaldyr de Jesus Gomes
dc.contributor.authorSilva, Albérico B. F. da
dc.contributor.authorEllena, Javier Alcides
dc.contributor.authorSilva, Thales E. M.
dc.contributor.authorBatista, Alzir Azevedo
dc.date.accessioned2021-12-16T15:35:19Z
dc.date.available2021-12-16T15:35:19Z
dc.date.issued2020pt_BR
dc.description.abstractThe preparation, characterization, theoretical calculations and biological application of four RuII complexes with 2-picolinate (pic), 2,2’-bipyridine (bipy) and P-P as ligands [P-P = 1,1-bis(diphenylphosphino)methane (dppm-1), 1,2-bis(diphenylphosphino)ethane (dppe-2), 1,3-bis(diphenylphosphino)propane (dppp-3) or 1,1’-bis(diphenylphosphino)ferrocene (dppf-4)], is here presented. The complexes 1-4, with general formula [Ru(pic)(P-P)(bipy)]PF6, were characterized by elemental analysis and by infrared (IR), UV-Vis, nuclear magnetic resonance (NMR 1 H and 13P{1 H}) spectroscopies, cyclic voltammetry and X-ray crystallography technique. Additionally, preliminary in vitro tests against human breast (MDA-MB-231) and murine ascitic sarcoma 180 (S180) tumor cell lines were carried out, and compared with cisplatin, a reference drug. The drug concentration at which 50% of the cells are viable relative to the control (IC50) values found for complexes 1, 2, 3 and 4 against MDA-MB-231 tumor cells were around 14.6, 7.6, 3.3 and 0.4 μM, respectively, while against S180 tumor cells these complexes showed IC50 values of 71.9, 31.3, 11.2 and 3.5 μM, respectively. Therefore, the complexes were more active against MDA-MB-231 than S180.pt_BR
dc.identifier.citationLIMA, B. A. V. et al. New heteroleptic RuII/diphosphine complexes with cytotoxicity against human breast and murine ascitic sarcoma 180 tumor cells. Journal of the Brazilian Chemical Society, v. 31, n. 7, p. 1352-1361, 2020. Disponível em: <http://static.sites.sbq.org.br/jbcs.sbq.org.br/pdf/2019-0506AR.pdf>. Acesso em: 10 jun. 2021.pt_BR
dc.identifier.doihttp://dx.doi.org/10.21577/0103-5053.20200020pt_BR
dc.identifier.issn1678-4790
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/14249
dc.language.isoen_USpt_BR
dc.rightsabertopt_BR
dc.rights.licenseThis is an open-access article distributed under the terms of the Creative Commons Attribution License. Fonte: o PDF do artigo.pt_BR
dc.subjectPicolinatept_BR
dc.subjectBiphosphinespt_BR
dc.titleNew heteroleptic RuII/diphosphine complexes with cytotoxicity against human breast and murine ascitic sarcoma 180 tumor cells.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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