Açaí (Euterpe oleracea Mart.) modulates oxidative stress resistance in Caenorhabditis elegans by direct and indirect mechanisms.

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dc.contributor.authorBonomo, Larissa de Freitas
dc.contributor.authorSilva, David Nunes
dc.contributor.authorBoasquivis, Patrícia Ferreira
dc.contributor.authorPaiva, Franciny Aparecida
dc.contributor.authorGuerra, Joyce Ferreira da Costa
dc.contributor.authorMartins, Talita Alves Faria
dc.contributor.authorTorres, Álvaro Gustavo de Jesus
dc.contributor.authorPaula, Igor Thadeu Borges Raposo de
dc.contributor.authorCaneschi, Washington Luiz
dc.contributor.authorJacolot, Philippe
dc.contributor.authorGrossin, Nicolas
dc.contributor.authorTessier, Frederic J.
dc.contributor.authorBoulanger, Eric
dc.contributor.authorSilva, Marcelo Eustáquio
dc.contributor.authorPedrosa, Maria Lúcia
dc.contributor.authorOliveira, Riva de Paula
dc.date.accessioned2015-03-31T21:04:58Z
dc.date.available2015-03-31T21:04:58Z
dc.date.issued2014
dc.description.abstractAçaí (Euterpe oleracea Mart.) has recently emerged as a promising source of natural antioxidants. Despite its claimed pharmacological and nutraceutical value, studies regarding the effects of açaí in vivo are limited. In this study, we use the Caenorhabditis elegans model to evaluate the in vivo antioxidant properties of açaí on an organismal level and to examine its mechanism of action. Supplementation with ac¸aı´ aqueous extract (AAE) increased both oxidative and osmotic stress resistance independently of any effect on reproduction and development. AAE suppressed bacterial growth, but this antimicrobial property did not influence stress resistance. AAE-increased stress resistance was correlated with reduced ROS production, the prevention of sulfhydryl (SH) level reduction and gcs-1 activation under oxidative stress conditions. Our mechanistic studies indicated that AAE promotes oxidative stress resistance by acting through DAF-16 and the osmotic stress response pathway OSR-1/UNC-43/SEK-1. Finally, AAE increased polyglutamine protein aggregation and decreased proteasome activity. Our findings suggest that natural compounds available in AAE can improve the antioxidant status of a whole organism under certain conditions by direct and indirect mechanisms.pt_BR
dc.identifier.citationBONOMO, L. de F. et al. Açaí (Euterpe oleracea Mart.) modulates oxidative stress resistance in Caenorhabditis elegans by direct and indirect mechanisms. Plos One, v. 9, p. e89933, 2014. Disponível em: <http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0089933>. Acesso em: 15 out. 2014.pt_BR
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0089933
dc.identifier.issn1932-6203
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/4834
dc.language.isoen_USpt_BR
dc.rights.licenseOs trabalhos publicados na Plos one estão sob Licença Creative Commons que permite copiar, distribuir e transmitir o trabalho, desde que sejam citados o autor e licenciante. Não permite o uso para fins comerciais nem a adaptação. Fonte: Plos one <https://www.plos.org/open-access>. Acesso em: 03 jan. 2017.pt_BR
dc.titleAçaí (Euterpe oleracea Mart.) modulates oxidative stress resistance in Caenorhabditis elegans by direct and indirect mechanisms.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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