In vitro photoprotective evaluation and development of novel nanoemulsion with chromone derivative.

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dc.contributor.authorAntunes, Amanda dos Santos
dc.contributor.authorGouveia, Ana Paula Araújo
dc.contributor.authorDiogo, Gabriela Maciel
dc.contributor.authorTaylor, Jason Guy
dc.contributor.authorSousa, Lucas Resende Dutra
dc.contributor.authorAmparo, Tatiane Roquete
dc.contributor.authorPerasoli, Fernanda Barçante
dc.contributor.authorSantos, Orlando David Henrique dos
dc.contributor.authorCazati, Thiago
dc.contributor.authorVieira, Paula Melo de Abreu
dc.contributor.authorPenido, Ricardo Gonçalves
dc.contributor.authorSantos, Viviane Martins Rebello dos
dc.date.accessioned2021-12-21T18:50:37Z
dc.date.available2021-12-21T18:50:37Z
dc.date.issued2021pt_BR
dc.description.abstractChromone derivatives exhibiting high absorbance values in the UVA/UVB region were synthesized, and their photoprotective properties were evaluated. Chromones were prepared according to known literature procedures and characterized by high resolution mass spectrometry, infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy. The in vitro solar protection factor (SPF) was determined by the Mansur method and cytotoxicity was evaluated using the sulforhodamine B assay. Two of the chromones synthesized demonstrated suitable SPF values and displayed no cytotoxic effect towards MRC-5 human fibroblasts at the tested concentrations, indicating great potential for future in vivo assays and clinical trials. Finally, the lead compound was incorporated into a nanoemulsion. Nanoemulsions showed high droplet size homogeneity and excellent stability. Chromones bearing methoxy substituents were found to be the most promising compounds with ideal photoprotective properties desirable for utilization and incorporation in sunscreen formulations.pt_BR
dc.identifier.citationANTUNES, A. dos S. et al. In vitro photoprotective evaluation and development of novel nanoemulsion with chromone derivative. Journal of the Brazilian Chemical Society, v. 32, n. 9, p. 1813-1821, 2021. Disponível em: <http://static.sites.sbq.org.br/jbcs.sbq.org.br/pdf/2021-0089AR.pdf>. Acesso em: 10 jun. 2021.pt_BR
dc.identifier.doihttps://dx.doi.org/10.21577/0103-5053.20210072pt_BR
dc.identifier.issn1678-4790
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/14284
dc.language.isoen_USpt_BR
dc.rightsabertopt_BR
dc.rights.licenseThis is an open-access article distributed under the terms of the Creative Commons Attribution License. Fonte: o PDF do artigo.pt_BR
dc.subjectMansurpt_BR
dc.subjectOrganic UV filterspt_BR
dc.subjectCytotoxicitypt_BR
dc.titleIn vitro photoprotective evaluation and development of novel nanoemulsion with chromone derivative.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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