Protein restriction during pregnancy affects lung development and promotes oxidative stress and inflammation in C57 BL/6 mice offspring.

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dc.contributor.authorCastro, Thalles de Freitas
dc.contributor.authorMatos, Natália Alves de
dc.contributor.authorSouza, Ana Beatriz Farias de
dc.contributor.authorCosta, Guilherme de Paula
dc.contributor.authorPerucci, Luiza Oliveira
dc.contributor.authorSilva, André Talvani Pedrosa da
dc.contributor.authorCangussú, Silvia Dantas
dc.contributor.authorMenezes, Rodrigo Cunha Alvim de
dc.contributor.authorBezerra, Frank Silva
dc.date.accessioned2023-03-20T14:01:27Z
dc.date.available2023-03-20T14:01:27Z
dc.date.issued2022pt_BR
dc.description.abstractObjectives: The present study aimed to evaluate the effects of maternal protein restriction during pregnancy on the lungs of 1-d and 31-d old offspring of C57BL/6 mice. Methods: The C57BL/6 mice (810 wk) were used for breeding. After pregnancy confirmation, female mice were randomly divided into a control group (CG) receiving a standard diet (22% protein) and a protein- restriction group (PRG) receiving a low-protein diet (6% protein). In the low-protein diet, protein was replaced by carbohydrate. After parturition, female mice that received the low-protein diet were fed the standard diet. Male offspring were euthanized 1 d and 31 d after birth for subsequent analysis. We evaluated the effects of a protein-restricted diet during gestation in pulmonary organogenesis, lung oxidative stress, and pulmonary inflammatory response of the offspring. Results: PRG mice 1 d after birth showed lower body and lung mass, length, relative mass, lung density, and erythrocyte count compared with CG mice. There was an increase in alveolar airspace density and a higher mean linear intercept (Lm), greater oxidative damage, and inflammation in PRG mice compared with CG mice. At 31 d after birth, PRG mice had lower body mass, length, and lung mass values compared with CG mice. PRG mice showed greater recruitment of inflammatory cells to the airways. In addition, there was increased collagen deposition in the lungs, altered inflammatory mediators, and greater oxidative damage compared with CG mice. Conclusions: Protein restriction during pregnancy reduces the body weight of offspring and promotes inflam- mation and oxidative stress, resulting in a simplification of the lung structure.pt_BR
dc.identifier.citationCASTRO, T. de F. et al. Protein restriction during pregnancy affects lung development and promotes oxidative stress and inflammation in C57 BL/6 mice offspring. Nutrition, v. 101, artigo 111682, set. 2022. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0899900722000946?via%3Dihub>. Acesso em: 11 out. 2022.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.nut.2022.111682pt_BR
dc.identifier.issn0899-9007
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/16392
dc.identifier.uri2https://www.sciencedirect.com/science/article/pii/S0899900722000946?via%3Dihubpt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectLung oxidative stresspt_BR
dc.subjectInflammationpt_BR
dc.subjectFetal programmingpt_BR
dc.titleProtein restriction during pregnancy affects lung development and promotes oxidative stress and inflammation in C57 BL/6 mice offspring.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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