Accelerated Blood Clearance (ABC) phenomenon favors the accumulation of tartar emetic in pegylated liposomes in BALB/c mice liver.
| dc.contributor.author | Lopes, Tamara Cristina Moreira | |
| dc.contributor.author | Silva, Débora Faria | |
| dc.contributor.author | Costa, Walyson Coelho | |
| dc.contributor.author | Frezard, Frederic Jean Georges | |
| dc.contributor.author | Barichello, José Mario | |
| dc.contributor.author | Barcellos, Neila Marcia Silva | |
| dc.contributor.author | Lima, Wanderson Geraldo de | |
| dc.contributor.author | Rezende, Simone Aparecida | |
| dc.date.accessioned | 2018-04-26T13:24:26Z | |
| dc.date.available | 2018-04-26T13:24:26Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | Tartar emetic (TE) was the first drug used to treat leishmaniasis.However, its use was discontinued due to high toxicity. Association of TE with liposomes is a strategy to reduce its side effects. Pegylated liposomes (Lpeg) present lower rates of uptake by macrophages and prolonged circulation compared to their nonpegylated counterparts. However, repeated administration of Lpeg can cause an Accelerated Blood Clearance (ABC) phenomenon, whereby recognition of liposomes by antibodies results in faster phagocytosis. Thiswork evaluated the effect of TE administration on histopathological aspects and the effect of the ABC phenomenon on targeting and toxicity in mice. Our results show that treatment with free or liposomal TE had no effect on the erythrocyte count, on liver and spleen weight, and on hepatic, splenic, and cardiac histology in mice. Severe lesions were observed on the kidneys of animals treated with a single dose of free TE. Treatment with TE in Lpeg after induction of ABC phenomenon caused a significant increase in Sb level in the liver without toxicity. Furthermore, mice treated with TE in liposomes showed normal renal histopathology. These results suggest site-specific targeting of Sb to the liver after induction of ABC phenomenon with no toxicity to other organs. | pt_BR |
| dc.identifier.citation | LOPES, T. C. M. et al. Accelerated Blood Clearance (ABC) phenomenon favors the accumulation of tartar emetic in pegylated liposomes in BALB/c mice liver. Pathology Research International, v. 2018, p. 1-7, 2018. Disponível em: <https://www.hindawi.com/journals/pri/2018/9076723/>. Acesso em: 05 abr. 2018. | pt_BR |
| dc.identifier.issn | 20908091 | |
| dc.identifier.uri | http://www.repositorio.ufop.br/handle/123456789/9862 | |
| dc.language.iso | en_US | pt_BR |
| dc.rights | aberto | pt_BR |
| dc.rights.license | This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: o próprio artigo. | pt_BR |
| dc.title | Accelerated Blood Clearance (ABC) phenomenon favors the accumulation of tartar emetic in pegylated liposomes in BALB/c mice liver. | pt_BR |
| dc.type | Artigo publicado em periodico | pt_BR |