Extracts from the leaves of Campomanesia velutina inhibits production of LPS/INF-γ induced inflammatory mediators in J774A.1 cells and exerts anti-inflammatory and antinociceptive effects in vivo.

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dc.contributor.authorMichel, Marcela Carolina de Paula
dc.contributor.authorGuimarães, Andrea Grabe
dc.contributor.authorPaula, Carmem Aparecida de
dc.contributor.authorRezende, Simone Aparecida
dc.contributor.authorSobral, Marcos Eduardo Guerra
dc.contributor.authorGuimarães, Dênia Antunes Saúde
dc.date.accessioned2014-11-24T17:52:57Z
dc.date.available2014-11-24T17:52:57Z
dc.date.issued2013
dc.description.abstractCampomanesia velutina (Cambess) O. Berg, Myrtaceae, popularly known as “gabiroba” or “guavira”, is used in traditional Brazilian medicine to treat several diseases, including inflammation and rheumatism. Extraction and isolation from leaves of the plant afforded the active compound myricetin 3-O-rhamnoside, also known as myricitrin. The ethanolic extract of leaves of C. velutina and its ethyl acetate and methanolic fractions were evaluated in inflammation (carrageenan-induced paw oedema) and analgesic models (acetic acid-induced abdominal writhing and hot plate test). Moreover, the ethanolic extract, its fractions and the isolated compound were also in vitro evaluated for their ability to modulate NO, TNF-α and IL-10 production from J774A.1 macrophages stimulated by LPS/IFN-γ. In vivo assays showed remarkable anti-inflammatory activity of ethanolic extract, ethyl acetate and methanolic fractions. The antinociceptive activity of ethanolic extract and A was demonstrated in acetic acid-induced abdominal writhing test. In vitro assays demonstrated that ethyl acetate and methanolic fractions fraction and myricitrin inhibited NO production from macrophages J774A.1. Also Myricitrin induced production of IL-10 anti-inflammatory cytokine. None of the samples was able to inhibited TNF-α production. The results demonstrated for the first time the anti-inflammatory and antinociceptive activity of C. velutina.pt_BR
dc.identifier.citationMICHEL, M. C. de P. el al. Extracts from the leaves of Campomanesia velutina inhibits production of LPS/INF-γ induced inflammatory mediators in J774A.1 cells and exerts anti-inflammatory and antinociceptive effects in vivo. Revista Brasileira de Farmacognosia, v. 23, p. 927-936, 2013. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000600927>. Acesso em: 1 set. 2014.pt_BR
dc.identifier.doihttp://dx.doi.org/10.1590/S0102-695X2013000600010
dc.identifier.issn1981-528X.
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/4034
dc.language.isoen_USpt_BR
dc.rights.licenseA Revista Brasileira de Farmacognosia permite que o Repositório Institucional da Universidade Federal de Ouro Preto (UFOP) deposite uma cópia eletrônica dos artigos publicados por esse periódico  em que ao menos um dos autores faça parte da comunidade cientifica da UFOP. Fonte: Licença concedida Mediante prenchimento de formulário em 16 ago. 2013.pt_BR
dc.subjectCampomanesia velutinapt_BR
dc.subjectMyricitrinpt_BR
dc.subjectAnti inflammatorypt_BR
dc.subjectAntinociceptivept_BR
dc.subjectInflammatory mediatorspt_BR
dc.titleExtracts from the leaves of Campomanesia velutina inhibits production of LPS/INF-γ induced inflammatory mediators in J774A.1 cells and exerts anti-inflammatory and antinociceptive effects in vivo.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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