Baclofen into the lateral parabrachial nucleus induces hypertonic sodium chloride and sucrose intake in rats.

Simple item page
dc.contributor.authorOliveira, Lisandra Brandino de
dc.contributor.authorKimura, Everton Heidi
dc.contributor.authorCallera, João Carlos
dc.contributor.authorLuca Junior, L. A. de
dc.contributor.authorColombari, Débora Simões de Almeida
dc.date.accessioned2015-03-03T16:45:35Z
dc.date.available2015-03-03T16:45:35Z
dc.date.issued2011
dc.description.abstractGABAA and GABAB receptors are present in the lateral parabrachial nucleus (LPBN), a pontine area involved with inhibitory mechanisms related to the control of sodium appetite. Activation of GABAA receptors in the LPBN induces strong ingestion of 0.3 M sodium chloride (NaCl) in normonatremic and euhydrated rats. In the present study, we investigated the effects of the GABAB receptor agonist baclofen, injected alone or combined with GABAA or GABAB receptor antagonists into the LPBN on 0.3 M NaCl, water, 0.06 M sucrose and food intake in normonatremic and euhydrated rats. Male Holtzman rats with stainless steel cannulas implanted bilaterally in the LPBN were used. In normonatremic and euhydrated rats, bilateral injections of baclofen (0.5 nmol/0.2 _l) into the LPBN induced 0.3 M NaCl (24.0_3.1 vs. saline: 2.0_0.8 ml/240 min) and water intake (10.6_1.4 vs. saline: 3.5_0.7 ml/240 min) in a two-bottle test. Injections of GABAB receptor antagonists CGP 35348 (50 nmol/0.2 _l) or 2-hydroxysaclofen (5 nmol/0.2 _l) or GABAA receptor antagonist bicuculline (1.6 nmol/0.2 _l) into the LPBN reduced 0.3 M NaCl (14.1_4.7 ml/240 min; 9.97_2.5 ml/210 min; 8.8_5.9 ml/240 min, respectively) and water intake induced by baclofen injected into the LPBN. Baclofen (0.5 nmol/0.2 _l) injected into the LPBN also induced 0.06 M sucrose intake (21.8_5.9 vs. saline: 5.0_2.6 ml/180 min). Urinary volume and sodium excretion had a tendency to decrease after baclofen injection into the LPBN, whereas arterial pressure and food intake were not affected. The results show that baclofen injected into the LPBN, in normonatremic and euhydrated rats, produces a natriorexigenic effect dependent on GABAA and GABAB receptor activation. The natriorexigenic effect is not secondary to alterations in blood pressure or sodium urinary excretion. In addition, baclofen injected into the LPBN also induces 0.06 M sucrose intake.pt_BR
dc.identifier.citationOLIVEIRA, L. B. et al. Baclofen into the lateral parabrachial nucleus induces hypertonic sodium chloride and sucrose intake in rats. Neuroscience, v. 183, p. 160-170, 2011. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0306452211001606>. Acesso em: 08 nov. 2014.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.neuroscience.2011.02.019
dc.identifier.issn0306-4522
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/4527
dc.language.isoen_USpt_BR
dc.rights.licenseO periódico Neuroscience concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3525980423596.pt_BR
dc.subjectSodium appetitept_BR
dc.subjectSucrose intakept_BR
dc.subjectWater intakept_BR
dc.subjectUrinary excretionpt_BR
dc.titleBaclofen into the lateral parabrachial nucleus induces hypertonic sodium chloride and sucrose intake in rats.pt_BR
dc.typeArtigo publicado em periodicopt_BR
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
ARTIGO_BaclofenLateralRats.pdf
Size:
1.1 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
2.57 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
DECBI - Artigos publicados em periódicos