Microexon gene transcriptional profiles and evolution provide insights into blood processing by the Schistosoma japonicum esophagus.

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dc.contributor.authorLi, Xiao Hong
dc.contributor.authorDeMarco, Ricardo
dc.contributor.authorNeves, Leandro Xavier
dc.contributor.authorJames, Sally R.
dc.contributor.authorNewling, Katherine
dc.contributor.authorAshton, Peter D.
dc.contributor.authorCao, Jian Ping
dc.contributor.authorWilson, R. Alan
dc.contributor.authorBorges, William de Castro
dc.date.accessioned2018-05-11T11:53:55Z
dc.date.available2018-05-11T11:53:55Z
dc.date.issued2018
dc.description.abstractAdult schistosomes have a well-developed alimentary tract comprising an oral sucker around the mouth, a short esophagus and a blind ending gut. The esophagus is not simply a muscular tube for conducting blood from the mouth to gut but is divided into compartments, surrounded by anterior and posterior glands, where processing of ingested blood is initiated. Self-cure of rhesus macaques from a Schistosoma japonicum infection appears to operate by blocking the secretory functions of these glands so that the worms cease feeding and slowly starve to death. Here we use subtractive RNASeq to characterise the genes encoding the principal secretory products of S. japonicum esophageal glands, preparatory to evaluating their relevance as targets of the self-cure process.pt_BR
dc.identifier.citationLI, X. H. et al. Microexon gene transcriptional profiles and evolution provide insights into blood processing by the Schistosoma japonicum esophagus. PLoS Neglected Tropical Diseases, v. 12, p. 1-22, 2018. Disponível em: <http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006235>. Acesso em: 05 abr. 2018.pt_BR
dc.identifier.issn19352735
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/9919
dc.language.isoen_USpt_BR
dc.rightsabertopt_BR
dc.rights.licenseThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Fonte: Plos One <http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172103> .Acesso em: 30 jul. 2017.pt_BR
dc.titleMicroexon gene transcriptional profiles and evolution provide insights into blood processing by the Schistosoma japonicum esophagus.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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