Identification of a bioactive compound isolated from Brazilian propolis type 6.
No Thumbnail Available
Date
2009
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
A prenylated benzophenone, hyperibone A, was isolated from the hexane fraction of Brazilianpropolistype6. Its structure was determined by spectral analysis including 2D NMR. This compound exhibited cytotoxic activity against HeLa tumor cells (IC50 = 0.1756 μM), strong antimicrobial activity (MIC range—0.73–6.6 μg/mL; MBC range—2.92–106 μg/mL) against Streptococcus mutans, Streptococcus sobrinus, Streptococcus oralis, Staphylococcus aureus, and Actinomyces naeslundii, and the results of its cytotoxic and antimicrobial activities were considered good.
Description
Keywords
Prenylated benzophenone hyperibone A, Biological activity, Brazilian propolis
Citation
CASTRO, M. L. et al. Identification of a bioactive compound isolated from Brazilian propolis type 6. Bioorganic & Medicinal Chemistry, v. 17, n. 14, p. 5332-5335, jul. 2009. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0968089609004350>. Acesso em: 09 out. 2012.