Splenectomy does not interfere with immune response to Leishmania major infection in mice.

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dc.contributor.authorMaioli, Tatiani Uceli
dc.contributor.authorCarneiro, Cláudia Martins
dc.contributor.authorAssis, Frankcinéia Aparecida de
dc.contributor.authorFaria, Ana Maria Caetano de
dc.date.accessioned2012-09-19T17:48:06Z
dc.date.available2012-09-19T17:48:06Z
dc.date.issued2007
dc.description.abstractSpleen is one of the largest lymphoid organs in the body; it harbors immune cells including antigen presenting cells, B and T lymphocytes. It has an important role in humoral and cellular immune responses. Herein we investigated the role of spleen in the immune response to experimental Leishmania major infection. It is known that C57BL/6 mice are resistant to L. major infection whereas BALB/c mice are susceptible. Although splenectomy was associated with reduced serum levels of IFN-gamma, absence of the spleen did not change the profile of L. major infection in the resistant C57BL/6 and BALB/c susceptible mice. Both strains of mice maintained the same profile of cytokine production in regional lymph nodes after splenectomy and responded in the same way against the infection. Only splenectomized BALB/c mice had a reduction in IL-4 and IL-10 production by lymph node cells early in infection. Our data suggest that, in localized infections, regional lymph nodes may replace efficiently the immunological role of spleen in the cellular and humoral immune responses.pt_BR
dc.identifier.citationMAIOLI, T. U. et al. Splenectomy does not interfere with immune response to Leishmania major infection in mice. Cellular Immunology, v. 249, n. 1, p. 1-7, set. 2007. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0008874907002225>. Acesso em: 19 set. 2012.pt_BR
dc.identifier.issn00088749
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/1409
dc.language.isoen_USpt_BR
dc.rights.licenseO periódico Cellular Immunology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3281990466243.
dc.subjectLeishmania majorpt_BR
dc.subjectImmune protectionpt_BR
dc.subjectSpleenpt_BR
dc.titleSplenectomy does not interfere with immune response to Leishmania major infection in mice.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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