Differential impact of metacyclic and blood trypomastigotes on parasitological, serological and phenotypic features triggered during acute Trypanosoma cruzi infection in dogs.

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dc.contributor.authorCarneiro, Cláudia Martins
dc.contributor.authorMartins Filho, Olindo Assis
dc.contributor.authorReis, Alexandre Barbosa
dc.contributor.authorVeloso, Vanja Maria
dc.contributor.authorAraújo, Flávio Marcos Gomes de
dc.contributor.authorBahia, Maria Terezinha
dc.contributor.authorLana, Marta de
dc.contributor.authorCoelho, George Luiz Lins Machado
dc.contributor.authorGazzinelli, Giovanni
dc.contributor.authorOliveira, Rodrigo Corrêa de
dc.contributor.authorTafuri, Wagner Luiz
dc.date.accessioned2012-07-10T14:08:49Z
dc.date.available2012-07-10T14:08:49Z
dc.date.issued2007
dc.description.abstractDifferential impact of metacyclic and blood trypomastigotes on parasitological, serological and phenotypic features triggered during acute Trypanosoma cruzi infection in dogs A detailed follow-up investigation of the major parasitological, serological and phenotypic features in dogs experimentally infected with metacyclic (MT) and blood (BT) trypomastigotes of Trypanosoma cruzi strain Berenice-78, typifying vectorial and transfusional transmission of human Chagas disease, has been conducted. Although there were no changes with respect to the window of patent-parasitaemia, significant differences between MT- and BT-infected dogs in both the prepatent period (days 23 and 19, respectively) and the day of maximum parasitaemia (days 26 and 22, respectively) were recorded. A progressive enhancement in the level of T. cruzi -specific antibodies accompanied infection by both MT and BT forms, although higher IgG titres developed on days 14 and 21 following infection with MT forms. Higher Thy-1 + /CD21 + and lower CD4 + /CD8 + cell ratios, occasioned by increased levels of Thy-1 + and CD8 + T-cells and reduced frequencies of CD4 + T-cells and CD21 + B-lymphocytes, were observed in both MT- and BT-infected animals. The reduced frequency of CD14 + leukocytes was revealed as the most relevant phenotypic feature intrinsic to T. cruzi infection independent of inoculum source. BT-specific phenotypic features included an early reductionpt_BR
dc.identifier.citationCARNEIRO, C. M. et al. Differential impact of metacyclic and blood trypomastigotes on parasitological, serological and phenotypic features triggered during acute Trypanosoma cruzi infection in dogs. Acta Tropica, v. 101, n. 2, p. 120-129, fev. 2007. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0001706X07000046>. Acesso em: 10 jul. 2012.pt_BR
dc.identifier.issn0001706X
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/1036
dc.language.isoen_USpt_BR
dc.rights.licenseO periódico Acta Tropica concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3281990354506.
dc.subjectDogpt_BR
dc.subjectBlood (BT) and metacycling (MT) trypomastigotespt_BR
dc.subjectTrypanosoma cruzipt_BR
dc.subjectFlow cytometrypt_BR
dc.titleDifferential impact of metacyclic and blood trypomastigotes on parasitological, serological and phenotypic features triggered during acute Trypanosoma cruzi infection in dogs.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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