Nitrotriazole-based compounds as antichagasic agents in a long-treatmenti In vivo assay.

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dc.contributor.authorPapadopoulou, Maria V.
dc.contributor.authorBloomer, William D.
dc.contributor.authorRosenzweig, Howard S.
dc.contributor.authorMazzeti, Ana Lia
dc.contributor.authorGonçalves, Karolina Ribeiro
dc.contributor.authorMendes, Priscila Fagundes
dc.contributor.authorBahia, Maria Terezinha
dc.date.accessioned2017-12-20T14:51:15Z
dc.date.available2017-12-20T14:51:15Z
dc.date.issued2017
dc.description.abstract3-Nitrotriazole-based compounds belonging to various chemical subclasses were found to be very effective against Chagas disease both in vitro and in vivo after a short administration schedule. In this study, five compounds with specific characteristics were selected to be administered for longer periods of time to mice infected with the virulent Trypanosoma cruzi Y strain to further evaluate their effectiveness as antichagasic agents and whether or not potential adverse effects occur. Benznidazole was included for comparison purposes. Complete parasitemia depletion, weight gain, 100% survival, and a lack of myocardial inflammation were observed with four of the compounds and benznidazole administered intraperitoneally at 15 or 20 mg/kg of body weight/day for 40 days. There was a significant reduction in the number of treatment days (number of doses) necessary to induce parasitemia suppression with all four compounds compared to that required with benznidazole. Partial cures were obtained with only one compound tested at 15 mg/kg/day and on the schedule mentioned above but not with benznidazole. Taken together, our data suggest that these compounds demonstrate potent trypanocidal activity comparable to or better than that of the reference drug, benznidazole, when they are administered at the same dose and on the same schedule.pt_BR
dc.identifier.citationPAPADOPOULOU, M. V. et al. Nitrotriazole-based compounds as antichagasic agents in a long-treatmenti In vivo assay. Antimicrobial Agents And Chemotherapy, v. 61, p. AAC.02717-16, 2017. Disponível em: <https://aac.asm.org/content/61/5/e02717-16>. Acesso em: 15 set. 2017.pt_BR
dc.identifier.doihttps://doi.org/10.1128/AAC.02717-16
dc.identifier.issn1098-6596
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/9221
dc.identifier.uri2https://aac.asm.org/content/61/5/e02717-16
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectBenznidazolept_BR
dc.subjectChagas diseasept_BR
dc.titleNitrotriazole-based compounds as antichagasic agents in a long-treatmenti In vivo assay.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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