Different reactive species modulate the hypotensive effect triggered by angiotensins at CVLM of 2K1C hypertensive rats.

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dc.contributor.authorSousa, Graziele Galdino de
dc.contributor.authorBarbosa, Maria Andréa
dc.contributor.authorBarbosa, Claudiane Maria
dc.contributor.authorLima, Taynara Carolina
dc.contributor.authorSantos, Robson Augusto Souza dos
dc.contributor.authorSantos, Maria José Campagnole dos
dc.contributor.authorAlzamora, Andréia Carvalho
dc.date.accessioned2021-09-23T17:22:56Z
dc.date.available2021-09-23T17:22:56Z
dc.date.issued2020pt_BR
dc.description.abstractHypertension is associated with increased central activity of the renin-angiotensin system (RAS) and oxidative stress. Here, we evaluated whether reactive species and neurotransmitters could contribute to the hypotensive effect induced by angiotensin (Ang) II and Ang-(1− 7) at the caudal ventrolateral medulla (CVLM) in renovascular hypertensive rats (2K1C). Therefore, we investigated the effect of Ang II, Ang-(1-7), and the Ang-(1-7) antagonist A-779 microinjected before and after CVLM microinjection of the nitric oxide (NO)-synthase inhibitor, (L-NAME), vitamin C (Vit C), bicuculline, or kynurenic acid in 2K1C and SHAM rats. Baseline values of the mean arterial pressure (MAP) in 2K1C rats were higher than in SHAM rats. CVLM microinjection of Ang II, Ang-(1− 7), L-NAME, or bicuculline induced decreases in the MAP in SHAM and 2K1C rats. In addition, Vit C and A-779 produced decreases in the MAP only in 2K1C rats. Kynurenic acid increased the MAP in both SHAM and 2K1C rats. Only the Ang-(1− 7) effect was increased by L-NAME and reduced by bicuculline in SHAM rats. L-NAME also reduced the A-779 effect in 2K1C rats. Only the Ang II effect was abolished by CVLM Vit C and enhanced by CVLM kynurenic acid in SHAM and 2K1C rats. Overall, the superoxide anion and glutamate participated in the hypotensive effect of Ang II, while NO and GABA participated in the hypotensive effect of Ang-(1− 7) in CVLM. The higher hypotensive response of A-779 in the CVLM of 2K1C rats suggests that Ang-(1− 7) contributes to renovascular hypertension.pt_BR
dc.identifier.citationSOUSA, G. G. de et al. Different reactive species modulate the hypotensive effect triggered by angiotensins at CVLM of 2K1C hypertensive rats. Peptides, v. 134, id 170409, dez. 2020. Disponível em: <https://www.sciencedirect.com/science/article/abs/pii/S0196978120301583>. Acesso em: 10 jun. 2021.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.peptides.2020.170409pt_BR
dc.identifier.issn0196-9781
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/13797
dc.identifier.uri2https://www.sciencedirect.com/science/article/abs/pii/S0196978120301583pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectCaudal ventrolateral medullapt_BR
dc.subjectVitamin Cpt_BR
dc.subjectGlutamatept_BR
dc.titleDifferent reactive species modulate the hypotensive effect triggered by angiotensins at CVLM of 2K1C hypertensive rats.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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