L-arginine supplementation increases cardiac collagenogenesis in mice chronically infected with Berenice-78 Trypanosoma cruzi strain.

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dc.contributor.authorNarde, Maiara Bianchini
dc.contributor.authorDomingues, Elisa Liz Belli Cassa
dc.contributor.authorGonçalves, Karolina Ribeiro
dc.contributor.authorVian, Mirelle Lomar
dc.contributor.authorZanini, Marcos Santos
dc.contributor.authorLima, Wanderson Geraldo de
dc.contributor.authorBahia, Maria Terezinha
dc.contributor.authorSantos, Fabiane Matos dos
dc.date.accessioned2023-05-03T20:41:51Z
dc.date.available2023-05-03T20:41:51Z
dc.date.issued2021pt_BR
dc.description.abstractChagas disease, caused by Trypanosoma cruzi, is a major neglected tropical disease that occurs mainly as chronic infection and systemic infection. Currently, there is no suitable and effective drug to treat this parasitic disease. Administration of nutrients with immunomodulatory properties, such as arginine and nitric oxide radicals, may be helpful as antiparasitic therapy. In this study, we evaluated the effects of arginine supplementation during the acute phase of infection under the development of chronic Chagas’ heart disease in Swiss mice inoculated with the Berenice-78 strain of T. cruzi. The effectiveness of arginine was determined by daily detection of the parasite in the blood and long-term serum levels of nitric oxide and tumor necrosis factor-alpha, in addition to evaluation of heart tissue damage. Arginine could flatten parasitemia and prevent elevation of tumor necrosis factor-alpha in T. cruzi-infected mice. Regarding chronic inflammatory myocardial derangements, similar findings were verified among T. cruzi-infected groups. Arginine promoted collagenogenesis in the heart muscle tissue of T. cruzi-infected arginine-supplemented group. These data show the paradoxical benefits of arginine in improving the outcome of Chagas chronic cardiomyopathy.pt_BR
dc.identifier.citationNARDE, M. B. et al. L-arginine supplementation increases cardiac collagenogenesis in mice chronically infected with Berenice-78 Trypanosoma cruzi strain. Parasitology International, v. 83, artigo 102345, 2021. Disponível em: <https://www.sciencedirect.com/science/article/pii/S1383576921000647>. Acesso em: 11 out. 2022.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.parint.2021.102345pt_BR
dc.identifier.issn1383-5769
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/16512
dc.identifier.uri2https://www.sciencedirect.com/science/article/pii/S1383576921000647pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectArgininept_BR
dc.subjectNitric oxidept_BR
dc.subjectChagas diseasept_BR
dc.subjectTrypanosoma cruzipt_BR
dc.subjectCardiomyopathypt_BR
dc.titleL-arginine supplementation increases cardiac collagenogenesis in mice chronically infected with Berenice-78 Trypanosoma cruzi strain.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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