Antitumoral activity of micellar solutions containing allyl isothiocyanate : an in vitro study.

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dc.contributor.authorAlmeida, Tamires Cunha
dc.contributor.authorOliveira, Daiane Teixeira de
dc.contributor.authorSávio, André Luiz Ventura
dc.contributor.authorPerasoli, Fernanda Barçante
dc.contributor.authorSilva, Glenda Nicioli da
dc.contributor.authorBarichello, José Mario
dc.date.accessioned2021-09-14T15:00:11Z
dc.date.available2021-09-14T15:00:11Z
dc.date.issued2021pt_BR
dc.description.abstractIntroduction: Several natural products exhibit promising antineoplastic activity against bladder cancer cells, including allyl isothiocyanate (AITC). However, the AITC irritates the mucous membranes and induces eczematous or vesicular skin reactions. Thus, pharmaceutical formulations are necessary to overcome these problems. The aim was to develop micellar solutions containing AITC and investigate their antitumoral activity in bladder carcinoma cell lines. Method: The micellar solutions were prepared by cold dispersion method. Subsequently, we evaluated cytotoxicity, cell proliferation, cell cycle kinetics and long-term effects of micelles in bladder cancer cells. Results: Cytotoxicity and cell proliferation assays showed there was an increase in AITC activity when it was encapsulated in micelles. We also observed cell cycle arrest in the S phase after treatment with AITC-micelles. Furthermore, the formulation was able to maintain the long-term effects of free AITC. Conclusions: The micellar solutions developed can become an interesting approach for administration of AITC in the treatment of bladder cancer.pt_BR
dc.description.abstractenIntroducción: Varios productos naturales exhiben actividad antineoplásica prometedora contra las células cancerosas de vejiga, incluido el isotiocianato de alilo (AITC). Sin embargo, el AITC irrita las membranas mucosas e induce reacciones cutáneas vesiculares o eccematosas. Por tanto, las formulaciones farmacéuticas son necesarias para superar estos problemas. El objetivo era desarrollar soluciones micelares que contengan AITC e investigar su actividad antitumoral en líneas celulares de carcinoma de vejiga. Método: Las soluciones micelares se prepararon mediante el método de dispersión en frío. Posteriormente, evaluamos la citotoxicidad, la proliferación celular, la cinética del ciclo celular y los efectos a largo plazo de las micelas en las células del cáncer de vejiga. Resultados: Los ensayos de citotoxicidad y proliferación celular mostraron que hubo un aumento en la actividad de AITC cuando se encapsuló en micelas. También observamos la detención del ciclo celular en la fase S después del tratamiento con micelas AITC. Además, la formulación pudo mantener los efectos a largo plazo del AITC libre Conclusiones: Las soluciones micelares desarrolladas pueden convertirse en un enfoque interesante para la administración de AITC en el tratamiento del cáncer de vejiga.pt_BR
dc.identifier.citationALMEIDA, T. C. et al. Antitumoral activity of micellar solutions containing allyl isothiocyanate: an in vitro study. ARS Pharmaceutica, v. 62, p. 40-51, 2021. Disponível em: <https://revistaseug.ugr.es/index.php/ars/article/view/15845>. Acesso em: 10 jun. 2021.pt_BR
dc.identifier.doihttps://doi.org/doi: 10.30827/ars.v62i1.15845pt_BR
dc.identifier.issn2340-9894
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/13718
dc.identifier.uri2https://revistaseug.ugr.es/index.php/ars/article/view/15845pt_BR
dc.language.isoen_USpt_BR
dc.rightsabertopt_BR
dc.rights.licenseThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0). Fonte: o PDF do artigo.pt_BR
dc.subjectBladder cancerpt_BR
dc.subjectPoloxamerpt_BR
dc.subjectCáncer de vejigapt_BR
dc.subjectPoloxámeropt_BR
dc.titleAntitumoral activity of micellar solutions containing allyl isothiocyanate : an in vitro study.pt_BR
dc.title.alternativeActividad antitumoral de soluciones micelares que contienen isotiocianato de alilo : un estudio in vitro.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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