Epitope mapping and protective immunity elicited by adenovirus expressing the Leishmania amastigote specific A2 antigen : correlation with IFN- and cytolytic activity by CD8+ T cells.

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dc.contributor.authorResende, Daniela de Melo
dc.contributor.authorCaetano, Bráulia Costa
dc.contributor.authorDutra, Míriam Santos
dc.contributor.authorAbrantes, Christiane de Freitas
dc.contributor.authorVerly, Rodrigo Moreira
dc.contributor.authorResende, Jarbas Magalhães
dc.contributor.authorVeloso, Dorila Piló
dc.contributor.authorRezende, Simone Aparecida
dc.contributor.authorRomero, Oscar Bruna
dc.contributor.authorFernandes, Ana Paula
dc.contributor.authorGazzinelli, Ricardo Tostes
dc.date.accessioned2014-11-20T15:59:10Z
dc.date.available2014-11-20T15:59:10Z
dc.date.issued2008
dc.description.abstractA2was identified as an amastigote virulence factor of Leishmania (Leishmania) donovani and as a candidate antigen for vaccine development against visceral leishmaniasis. Here, predicted hydrophilic, class I and II MHC-binding synthetic peptides were used to define epitopes recognized by A2-specific antibodies, CD8+ T and CD4+ T cells, respectively. Immunization of BALB/c mice with adenovirus expressing A2 (AdA2) resulted in lowantibody response, contrasting with high levels of IFN-_ producing CD4+ T and CD8+ T cells specific for A2. Further, A2-specific CD8+ T cells from immunized mice were capable of lysing sensitized target cells in vivo. Finally, we demonstrated an association of A2-specific T cell responses and reduced parasitism in both liver and spleen from mice immunized with AdA2 and challenged with L. (L.) chagasi.pt_BR
dc.identifier.citationRESENDE, D. de M. et al. Epitope mapping and protective immunity elicited by adenovirus expressing the Leishmania amastigote specific A2 antigen : correlation with IFN- and cytolytic activity by CD8+ T cells. Vaccine, v. 26, p. 4585-4593, 2008. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0264410X08006932>. Acesso em: 28 ago. 2014.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.vaccine.2008.05.091
dc.identifier.issn0264-410X
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/4003
dc.language.isoen_USpt_BR
dc.rights.licenseO periódico Vaccine concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3460890061017.pt_BR
dc.subjectLeishmaniasispt_BR
dc.subjectRecombinant vaccinept_BR
dc.subjectEpitope mappingpt_BR
dc.titleEpitope mapping and protective immunity elicited by adenovirus expressing the Leishmania amastigote specific A2 antigen : correlation with IFN- and cytolytic activity by CD8+ T cells.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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