Activation ofGPR40 induces hypothalamic neurogenesis through p38‐ and BDNF‐dependent mechanisms.

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dc.contributor.authorEngel, Daiane Fátima
dc.contributor.authorBobbo, Vanessa Cristina Dias
dc.contributor.authorSolon, Carina Silva
dc.contributor.authorNogueira, Guilherme Augusto Silva
dc.contributor.authorAssis, Alexandre Moura
dc.contributor.authorMendes, Natália Ferreira
dc.contributor.authorZanesco, Ariane Maria
dc.contributor.authorPapangelis, Athanasios
dc.contributor.authorUlven, Trond
dc.contributor.authorVelloso, Licio Augusto
dc.date.accessioned2022-12-15T21:26:51Z
dc.date.available2022-12-15T21:26:51Z
dc.date.issued2020pt_BR
dc.description.abstractHypothalamic adult neurogenesis provides the basis for renewal of neurons involved in the regulation of whole-body energy status. In addition to hormones, cytokines and growth factors, components of the diet, particularly fatty acids, have been shown to stimulate hypothalamic neurogenesis; however, the mechanisms behind this action are unknown. Here, we hypothesized that GPR40 (FFAR1), the receptor for medium and long chain unsaturated fatty acids, could mediate at least part of the neurogenic activity in the hypothalamus. We show that a GPR40 ligand increased hypothalamic cell proliferation and survival in adult mice. In postnatal generated neurospheres, acting in synergy with brain-derived neurotrophic factor (BDNF) and interleukin 6, GPR40 activation increased the expression of doublecortin during the early diferentiation phase and of the mature neuronal marker, microtubule-associated protein 2 (MAP2), during the late diferentiation phase. In Neuro-2a proliferative cell-line GPR40 activation increased BDNF expression and p38 activation. The chemical inhibition of p38 abolished GPR40 efect in inducing neurogenesis markers in neurospheres, whereas BDNF immunoneutralization inhibited GPR40-induced cell proliferation in the hypothalamus of adult mice. Thus, GPR40 acts through p38 and BDNF to induce hypothalamic neurogenesis. This study provides mechanistic advance in the understating of how a fatty acid receptor regulates adult hypothalamic neurogenesis.pt_BR
dc.identifier.citationENGEL, D. F. et al. Activation ofGPR40 induces hypothalamic neurogenesis through p38‐ and BDNF‐dependent mechanisms. Scientific Reports, v. 10, 2020. Disponível em: <https://www.nature.com/articles/s41598-020-68110-2>. Acesso em: 11 out. 2022.pt_BR
dc.identifier.doihttps://doi.org/10.1038/s41598-020-68110-2pt_BR
dc.identifier.issn2045-2322
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/15919
dc.language.isoen_USpt_BR
dc.rightsabertopt_BR
dc.rights.licenseThis article is licensed under a Creative Commons Attribution 4.0 International License, w. Source: The article PDF.hich permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Fonte: o PDF do artigo.pt_BR
dc.titleActivation ofGPR40 induces hypothalamic neurogenesis through p38‐ and BDNF‐dependent mechanisms.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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