Malnutrition alters the cardiovascular responses induced by central injection of tityustoxin in Fischer rats.

Simple item page
dc.contributor.authorSilva, Fernanda Cacilda dos Santos
dc.contributor.authorGuidine, Patrícia Alves Maia
dc.contributor.authorRibeiro, Mara Fernandes
dc.contributor.authorFernandes, Luciano Gonçalves
dc.contributor.authorXavier, Carlos Henrique
dc.contributor.authorMenezes, Rodrigo Cunha Alvim de
dc.contributor.authorSilva, Marcelo Eustáquio
dc.contributor.authorSantos, Tasso Moraes
dc.contributor.authorMoraes, Márcio Flávio Dutra
dc.contributor.authorChianca Júnior, Deoclécio Alves
dc.date.accessioned2017-06-06T17:48:23Z
dc.date.available2017-06-06T17:48:23Z
dc.date.issued2013
dc.description.abstractScorpion envenoming and malnutrition are considered two important public health problems in Brazil, involving mainly children. Both these conditions are more common among the economically stratified lower income portion of the population, thus suggesting that these factors should be analyzed concomitantly. It is known that cardiorespiratory manifestations, as cardiac arrhythmias, arterial hypertension and hypotension, pulmonary edema and circulatory failure are the main “causa mortis” of scorpion envenomation. Additionally, there are evidences in the literature that deficiencies in dietary intake endanger the CNS and modify the cardiovascular homeostasis. Then, the objective of this work is to evaluate the protein malnourished effect on cardiovascular responses induced by tityustoxin (TsTX, an a-type toxin extracted from the Tityus serrulatus scorpion venom). Fischer rats (n ¼ 20) were injected i.c.v. with TsTX and divided in control and malnorished groups, which were, respectively, submitted to a control and a low-protein diet. Arterial pressure recordings were done until death of the animals. Although both groups presented an increased mean arterial pressure after TsTX injection, this increase was smaller and delayed in malnourished rats, when compared to control rats. In addition, heart rate increased only in rats from the control group. Finally, malnourished rats had an increase in survival time (9:9/13.5pt_BR
dc.identifier.citationSILVA, F. C. S. dos et al. Malnutrition alters the cardiovascular responses induced by central injection of tityustoxin in Fischer rats. Toxicon, v. 76, p. 343-349, 2013. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0041010113003656>. Acesso em: 19 fev. 2017.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.toxicon.2013.09.015
dc.identifier.issn0041-0101
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/7895
dc.identifier.uri2http://www.sciencedirect.com/science/article/pii/S0041010113003656pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectScorpion envenomationpt_BR
dc.titleMalnutrition alters the cardiovascular responses induced by central injection of tityustoxin in Fischer rats.pt_BR
dc.typeArtigo publicado em periodicopt_BR
Files
Collections
DECBI - Artigos publicados em periódicos