Swimming exercise demonstrates advantages over running exercise in reducing proteinuria and glomerulosclerosis in spontaneously hypertensive rats.
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Date
2018
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Abstract
Experimental studies in animal models have described the benefits of physical exercise (PE) to kidney diseases
associated with hypertension. Land- and water-based exercises induce different responses in renal function. Our aim
was to evaluate the renal alterations induced by different environments of PE in spontaneously hypertensive rats
(SHRs). The SHRs were divided into sedentary (S), swimming exercise (SE), and running exercise (RE) groups, and
were trained for 8 weeks under similar intensities (60 min/day). Arterial pressure (AP) and heart rate (HR) were
recorded. The renal function was evaluated through urinary volume at each week of training; sodium and potassium
excretions, plasma and urinary osmolarities, glomerular filtration rate (GFR), levels of proteinuria, and renal damage
were determined. SE and RE rats presented reduced mean AP, systolic blood pressure, and HR in comparison with
S group. SE and RE rats showed higher urine osmolarity compared with S. SE rats showed higher free water clearance
(P < 0.01), lower urinary density (P < 0.0001), and increased weekly urine volume (P < 0.05) in comparison with RE
and S groups. GFR was increased in both SE and RE rats. The proteinuria of SE (7.0 ± 0.8 mg/24 h) rats was
decreased at the 8th week of the PE in comparison with RE (9.6 ± 0.8 mg/24 h) and S (9.8 ± 0.5 mg/24 h) groups. The
glomerulosclerosis was reduced in SE rats (P < 0.02). SE produced different response in renal function in comparison
with RE, in which only swimming-trained rats had better profile for proteinuria and glomerulosclerosis.
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Keywords
Renal function, Glomeruloesclerosis, Physical training
Citation
TOTOU, N. L. et al. Swimming exercise demonstrates advantages over running exercise in reducing proteinuria and glomerulosclerosis in spontaneously hypertensive rats. Physiology International, v. 105, n. 1, p. 76-85, 2018. Disponível em: <https://akademiai.com/doi/10.1556/2060.105.2018.1.7> Acesso em: 14 nov. 2018.