Cell immune response in mice skin stimulated with different adjuvants by intradermal route.

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dc.contributor.authorMathias, Fernando Augusto Siqueira
dc.contributor.authorCardoso, Jamille Mirelle de Oliveira
dc.contributor.authorReis, Levi Eduardo Soares
dc.contributor.authorSouza, Juliana Vitoriano de
dc.contributor.authorMoreira, Nádia das Dores
dc.contributor.authorOstolin, Thais Lopes Valentim Di Paschoale
dc.contributor.authorBrito, Rory Cristiane Fortes de
dc.contributor.authorSoares, Rodrigo Dian de Oliveira Aguiar
dc.contributor.authorVieira, Paula Melo de Abreu
dc.contributor.authorCarneiro, Cláudia Martins
dc.contributor.authorRoatt, Bruno Mendes
dc.contributor.authorReis, Alexandre Barbosa
dc.date.accessioned2023-01-26T19:22:44Z
dc.date.available2023-01-26T19:22:44Z
dc.date.issued2022pt_BR
dc.description.abstractAdjuvants act in the innate immunity and, when combined to vaccine antigens, can produce a more intense response, improving the antigen presentation, directing the immune system, excellent for new vaccine formulations. This study evaluated the use of the intradermal route and the immune response triggered by a single dose of the adjuvants Aluminum Hydroxide (Al(OH)3 ), Montanide Pet Gel A (MPGA), Glucopyranosyl Lipid A Stable Emulsion (GLA-SE), and Resiquimod (R-848) in the mice skin. As control mice received sterile saline. MPGA and GLA-SE led to cell recruitment when compared with control group, with intense presence of neutrophils in first 12 hours, replaced by macrophages after 168 hours. R-848 and Al(OH)3 showed similar cell recruitment profiles. Regarding cytokine production, groups that received MPGA and GLA-SE produced high levels of IL-6, TNF-α, and IFN-γ. R-848 and Al(OH)3 groups displayed similar profile of cytokine production only at the first hour. Our results suggest that the intradermal route is efficient inducing immune system activation and GLA-SE was promising adjuvants for a type 1 immune response vaccine.pt_BR
dc.identifier.citationMATHIAS, F. A. S. et al. Cell immune response in mice skin stimulated with different adjuvants by intradermal route. Journal of Vaccines, Immunology and Immunopathology, v. 1, p. 170-2022, 2022. Disponível em: <https://www.gavinpublishers.com/article/view/cell-immune-response-in-mice-skin-stimulated-with-different-adjuvants-by-intradermal-route>. Acesso em: 11 out. 2022.pt_BR
dc.identifier.doihttps://doi.org/10.29011/2575-789X.000170pt_BR
dc.identifier.issn2575-789X
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/16058
dc.identifier.uri2https://www.gavinpublishers.com/article/view/cell-immune-response-in-mice-skin-stimulated-with-different-adjuvants-by-intradermal-routept_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectAluminum hydroxidept_BR
dc.subjectCytokinespt_BR
dc.subjectGlucopyranosyl Lipid A Stable Emulsionpt_BR
dc.subjectImmune responsept_BR
dc.subjectInflammatory cell infiltratespt_BR
dc.titleCell immune response in mice skin stimulated with different adjuvants by intradermal route.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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