Trypanosoma cruzi : serum levels of nitric oxide and expression of inducible nitric oxide synthase in myocardium and spleen of dogs in the acute stage of infection with metacyclic or blood trypomastigotes.

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dc.contributor.authorVieira, Paula Melo de Abreu
dc.contributor.authorFrancisco, Amanda Fortes
dc.contributor.authorSouza, Sheler Martins de
dc.contributor.authorMalaquias, Luiz Cosme Cotta
dc.contributor.authorReis, Alexandre Barbosa
dc.contributor.authorGiunchetti, Rodolfo Cordeiro
dc.contributor.authorVeloso, Vanja Maria
dc.contributor.authorLana, Marta de
dc.contributor.authorTafuri, Wagner Luiz
dc.contributor.authorCarneiro, Cláudia Martins
dc.date.accessioned2012-07-04T17:38:38Z
dc.date.available2012-07-04T17:38:38Z
dc.date.issued2009
dc.description.abstractThe par tic i pa tion of nitric oxide (NO) in the con trol of blood par a si te mia and par a sit ism dur ing the acute phase of infec tion in dogs inoc u lated with blood try pom astig otes ( BT) or meta cy clic try pom astig otes (MT group) of Bere nice -78 Try pan o soma cru zi strain has been eval u ated. Ani mals of the MT group (n = 4) pre sented increased lev els of serum NO through out the infec tion when com pared with the BT ( n = 4) or con trol (n = 4) groups, and a delay in par a si te mia peak com pared with the BT group. In spleen frag ments, tis sue par a sit ism was not observed but the MT group pre sented larger areas asso ci ated with induc ible NO syn thase (iNOS) in rela tion to BT and con trol groups. Heart frag ments of MT-infected ani mals exhib ited com par a tively low tis sue par a sit ism and high iNOS expres sion, while ani mals of the BT group pre sented high inflam ma tory infil trate, high tis sue par a sit ism and low iNOS expres sion. These results indi cate that the source of inoc u lum can inter- fere with the devel op ment of the acute phase of Cha gas dis ease, and may also trig ger a dis tinct par a site–host inter ac tion dur ing this phase.pt_BR
dc.identifier.citationVIEIRA, P. M. de A. et al. Trypanosoma cruzi : serum levels of nitric oxide and expression of inducible nitric oxide synthase in myocardium and spleen of dogs in the acute stage of infection with metacyclic or blood trypomastigotes. Experimental Parasitology, v. 121, n. 1, p. 76-82, 2009. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0014489408002464>. Acesso em: 04 jul. 2012.pt_BR
dc.identifier.issn00144894
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/968
dc.language.isoen_USpt_BR
dc.rights.licenseO periódico Experimental Parasitology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3281411396521.
dc.subjectChagas' diseasept_BR
dc.subjectTrypanosoma cruzipt_BR
dc.subjectBlood trypomastigotespt_BR
dc.subjectMetacyclic trypomastigotespt_BR
dc.subjectNitric oxidept_BR
dc.subjectInducible nitric oxide synthasept_BR
dc.titleTrypanosoma cruzi : serum levels of nitric oxide and expression of inducible nitric oxide synthase in myocardium and spleen of dogs in the acute stage of infection with metacyclic or blood trypomastigotes.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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