Lasting effects of ketamine and isoflurane administration on anxiety- and panic-like behavioral responses in Wistar rats.

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dc.contributor.authorChírico, Máira Tereza Talma
dc.contributor.authorGuedes, Mariana Reis
dc.contributor.authorVieira, Lucas Gabriel
dc.contributor.authorReis, Thayane Oliveira
dc.contributor.authorSantos, Aline Maria de
dc.contributor.authorSouza, Ana Beatriz Farias de
dc.contributor.authorRibeiro, Iara Mariana Léllis
dc.contributor.authorNoronha, Sylvana Izaura Salyba Rendeiro de
dc.contributor.authorNogueira, Katiane de Oliveira Pinto Coelho
dc.contributor.authorOliveira, Laser Antônio Machado de
dc.contributor.authorGomes, Fabiana Aparecida Rodrigues
dc.contributor.authorSilva, Fernanda Cacilda dos Santos
dc.contributor.authorChianca Júnior, Deoclécio Alves
dc.contributor.authorBezerra, Frank Silva
dc.contributor.authorMenezes, Rodrigo Cunha Alvim de
dc.date.accessioned2021-11-22T11:42:38Z
dc.date.available2021-11-22T11:42:38Z
dc.date.issued2021pt_BR
dc.description.abstractIn clinical and laboratory practice, the use of anesthetics is essential in order to perform surgeries. Anesthetics, besides causing sedation and muscle relaxation, promote several physiological outcomes, such as psychotomimetic alterations, increased heart rate, and blood pressure. However, studies depicting the behavioral effect induced by ketamine and isoflurane are conflicting. In the present study, we assessed the behavioral effects precipitated by ketamine and isoflurane administration. We have also evaluated the ketamine effect on cell cytotoxicity and viability in an amygdalar neuronal primary cell culture. Ketamine (80 mg/kg) caused an anxiogenic effect in rats exposed to the elevated T-maze test (ETM) 2 and 7 days after ketamine administration. Ketamine (40 and 80 mg/kg) administration also decreased panic-like behavior in the ETM. In the light/dark test, ketamine had an anxiogenic effect. Isoflurane did not change animal behavior on the ETM. Neither ketamine nor isoflurane changed the spontaneous locomotor activity in the open field test. However, isoflurane-treated animals explored less frequently the OF central area seven days after treatment. Neither anesthetic caused oxidative damage in the liver. Ketamine also reduced cellular metabolism and led to neuronal death in amygdalar primary cell cultures. Thus, our work provides evidence that ketamine and isoflurane induce pronounced long lasting anxiety-related behaviors in male rats.pt_BR
dc.identifier.citationCHÍRICO, M. T. T. et al. Lasting effects of ketamine and isoflurane administration on anxiety- and panic-like behavioral responses in Wistar rats. Life Sciences, v. 276, p. 119423, 2021. Disponível em: <https://www.sciencedirect.com/science/article/abs/pii/S0024320521004082>. Acesso em: 10 jun. 2021.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.lfs.2021.119423pt_BR
dc.identifier.issn0024-3205
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/13979
dc.identifier.uri2https://www.sciencedirect.com/science/article/abs/pii/S0024320521004082pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectAmygdala neuronspt_BR
dc.subjectCellular viabilitypt_BR
dc.subjectAnxiogenic-like responsept_BR
dc.titleLasting effects of ketamine and isoflurane administration on anxiety- and panic-like behavioral responses in Wistar rats.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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