Short-term effect of whey protein supplementation on the quality of life of patients waiting for liver transplantation : a double blinded randomized clinical trial.

Simple item page
dc.contributor.authorD´Alessandro, Michelle Carvalho de Oliveira
dc.contributor.authorGomes, Amanda Dias
dc.contributor.authorMorais, Jéssica França
dc.contributor.authorMizubuti, Yani Glaúcia Gomide
dc.contributor.authorSilva, Thales Antônio da
dc.contributor.authorMauricio, Silvia Fernandes
dc.contributor.authorMendes, Larissa Loures
dc.contributor.authorCorreia, Maria Isabel Toulson Davisson
dc.contributor.authorGeneroso, Simone de Vasconcelos
dc.date.accessioned2023-03-20T13:06:58Z
dc.date.available2023-03-20T13:06:58Z
dc.date.issued2021pt_BR
dc.description.abstractBackground: Chronic liver disease is associated with malnutrition that negatively impacts a patient’s health-related quality of life (HRQoL). Aim: To evaluate the short-term effect of whey protein supplementation on the HRQoL and nutritional and functional status of patients waiting for liver transplantation. Methods: This was a double-blind randomized clinical trial with patients waiting for liver transplantation who were randomized into two groups: WP (whey protein supplementation) and the control (casein supplementation). Both groups received 40 g (20 g in the morning and 20 g in the evening) for 15 days. Nutritional and functional status were evaluated. Energy balance was calculated as the difference between energy intake (24-hour recall) and total energy expenditure (assessed by indirect calorimetry). The chronic liver disease questionnaire was used to assess HRQoL. All measurements were performed before and after the intervention. Results: Fifty-six patients were evaluated. Malnutrition was present in 56.9%, and it was directly associated with a poor HRQoL (p<0.05). No improvement on the nutritional and functional status was observed, in either group after protein supplementation. HRQoL improved after WP and casein supplementation, with no differences between groups (p>0.05). Patients who met protein requirements and had a positive energy balance demonstrated a higher HRQoL score (4.9, p<0.05), without between-group differences. Conclusion: Malnutrition substantially reduces HRQoL. Short-term WP or casein supplementation improved similarly the HRQoL.pt_BR
dc.description.abstractenRacional: A doença hepática crônica está associada à desnutrição que afeta negativamente a qualidade de vida relacionada à saúde (QVRS). Objetivo: Avaliar o efeito da suplementação aguda de proteína do soro de leite na QVRS e no estado nutricional e funcional dos pacientes em lista de espera para o transplante hepático. Métodos: Ensaio clínico randomizado com pacientes à espera do transplante hepático que foram randomizados em dois grupos: PS (suplementação com proteína do soro de leite) e Controle (suplementação com caseína). Ambos os grupos receberam 40 g das proteínas (20 g pela manhã e 20 g à noite) por 15 dias. O estado nutricional e funcional foi avaliado. O balanço energético foi calculado como a diferença entre a ingestão energética (recordatório de 24 horas) e o gasto energético total (avaliado por calorimetria indireta). O questionário de doença hepática crônica (CDLQ) foi utilizado para avaliar a QVRS. Todas as medidas foram realizadas antes e após a intervenção. Resultados: Cinquenta e seis pacientes foram avaliados. A desnutrição esteve presente em 56,9% e, diretamente associada à baixa QVRS (p<0,05). A suplementação, com ambas as proteínas, não alterou o estado nutricional e funcional dos pacientes (p>0,05). Entretanto, a QVRS melhorou após a suplementação com PS e caseína, sem diferenças entre os grupos (p>0,05). Pacientes que alcançaram as necessidades proteicas e com balanço energético positivo tiveram maior escore de QVRS (4,9; p<0,05), sem diferenças entre os grupos (p>0,05). Conclusão: A desnutrição reduz substancialmente a QVRS. A suplementação aguda com PS ou caseína melhorou de forma similar a QVRS.pt_BR
dc.identifier.citationD’ALESSANDRO, M. C. de O. et al. Short-term effect of whey protein supplementation on the quality of life of patients waiting for liver transplantation: a double blinded randomized clinical trial. ABCD - Arquivos Brasileiros de Cirurgia Digestiva, v. 34, n. s, artigo e1596, 2021. Disponível em: <https://www.scielo.br/j/abcd/a/kbWK7FzqL44DX565prbvm9n/>. Acesso em: 11 out. 2022.pt_BR
dc.identifier.doihttps://doi.org/10.1590/0102-672020210002e1596pt_BR
dc.identifier.issn2317-6326
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/16390
dc.language.isoen_USpt_BR
dc.rightsabertopt_BR
dc.rights.licenseThis is an open-access article distributed under the terms of the Creative Commons Attribution License. Fonte: o PDF do artigo.pt_BR
dc.subjectNutritional statuspt_BR
dc.titleShort-term effect of whey protein supplementation on the quality of life of patients waiting for liver transplantation : a double blinded randomized clinical trial.pt_BR
dc.typeArtigo publicado em periodicopt_BR
Files
Original bundle
Now showing 1 - 2 of 2
No Thumbnail Available
Name:
ARTIGO_EfeitoCurtoPrazo.pdf
Size:
464.27 KB
Format:
Adobe Portable Document Format
Description:
Download
No Thumbnail Available
Name:
ARTIGO_ShortTermEffects.pdf
Size:
436.24 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
DENCS - Artigos publicados em periódicos