Benznidazole alters the pattern of Cyclophosphamide-induced reactivation in experimental Trypanosoma cruzi-dependent lineage infection.

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dc.contributor.authorSantos, Daniela Maria dos
dc.contributor.authorMartins, Tassiane Assíria Fontes
dc.contributor.authorCaldas, Ivo Santana
dc.contributor.authorDiniz, Lívia de Figueiredo
dc.contributor.authorCoelho, George Luiz Lins Machado
dc.contributor.authorCarneiro, Cláudia Martins
dc.contributor.authorOliveira, Riva de Paula
dc.contributor.authorSilva, André Talvani Pedrosa da
dc.contributor.authorLana, Marta de
dc.contributor.authorBahia, Maria Terezinha
dc.date.accessioned2012-07-09T15:30:28Z
dc.date.available2012-07-09T15:30:28Z
dc.date.issued2010
dc.description.abstractThe factors involved in the reactivation of chronic Chagas disease infection are not clear enough and may be related to host immune unbalance and/or parasite genetic diversity. To evaluate the role of the Trypanosoma cruzi genetic background in the Chagas disease reactivation, we inoculated Cyclophosphamide-immunos upressed (CyI) Swiss mice with clonal stocks from T. cruzi I (Cuica cl1, P209 cl1, Gamba cl1, SP104 cl1), T. cruzi II (IVV cl4, MVB cl8) and T. cruzi (Bug2148 cl1, MN cl2) lineages. We used the parasitemia as the parameter for Chagas disease reactivation and observed that CyI animals infected with T. cruzi stocks showed no reactivation and those infected with T. cruzi II stocks showed only 5% of reactivation. In contrast, immunosuppressed mice infected with stocks from T. cruzi I lineage showed 77.5 and 51.25% reactivation of the infection when Cyclophosphamide treatment was performed 60 and 180 days after inoculation, respectively. Next, we evaluated the efficacy of the Benznidazole (Bz) pre-treatment in reducing or preventing the recurrence of the infection in these CyI animals. In general, the percentage of the parasite recurrence was not altered among the CyI mice that received the Bz pretreatment during the acute phase of the infection. Interestingly, when pre-Bz treatment was performed during the chronic phase, we observed two different patterns of response: (i) an increased protection among the animals inoculated with the SP104 cl1 (genotype 19) and Cuica cl1 (genotype 20) stocks; (ii) an increased percentage of parasitemia reactivation among mice inoculated with Gamba cl1 (genotype 19) and P209 cl1 (genotype 20) T. cruzi stocks. Our results corroborate our hypothesis by showing that the T. cruzi genetic background in combination with specific Bz treatment has an important role in the Chagas disease reactivation in immunosuppressed animals.pt_BR
dc.identifier.citationSANTOS, D. M. dos et al. Benznidazole alters the pattern of Cyclophosphamide-induced reactivation in experimental Trypanosoma cruzi-dependent lineage infection. Acta Tropica, v. 113, n. 2, p. 134-138, fev. 2010. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0001706X09003271>. Acesso em: 09 jul. 2012.pt_BR
dc.identifier.issn0001706X
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/1010
dc.language.isoen_USpt_BR
dc.rights.licenseO periódico Acta Tropica concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3280860188365.
dc.subjectCyclophosphamide immunosuppressionpt_BR
dc.subjectBenznidazolept_BR
dc.subjectTrypanosoma cruzipt_BR
dc.subjectGenetic diversitypt_BR
dc.titleBenznidazole alters the pattern of Cyclophosphamide-induced reactivation in experimental Trypanosoma cruzi-dependent lineage infection.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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