Antiproliferative and photoprotective activities of the extracts and compounds from Calea fruticosa.

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dc.contributor.authorSeregheti, Thatiane M. Q.
dc.contributor.authorPinto, Ana Paula Resende Seibert
dc.contributor.authorGonçalves, Marlucy da Cru
dc.contributor.authorAntunes, Amanda dos Santos
dc.contributor.authorAlmeida, Wanessa Aparecida da Silveira
dc.contributor.authorMachado, Ranyelison Silva
dc.contributor.authorSilva, Jurandy N.
dc.contributor.authorFerreira, Paulo Michel Pinheiro
dc.contributor.authorPessoa, Claudia
dc.contributor.authorSantos, Viviane Martins Rebello dos
dc.contributor.authorNascimento, Andréa Mendes do
dc.date.accessioned2021-12-15T15:01:58Z
dc.date.available2021-12-15T15:01:58Z
dc.date.issued2020pt_BR
dc.description.abstractIn this paper, we complement our previous study on the antiproliferative activity of Calea fruticosa (Asteraceae) by isolating the compounds apigenin-4’,7-dimethyl ether (1), budlein A (2), quercetin (3), and cichoriin (4) from the plant’s aerial parts. The antiproliferative activity of these compounds was evaluated by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method against human tumor cell lines. Compound 3 displayed moderate antiproliferative activity in three cell lines (HCT 116, PC-3, and SF-295, with cell growth inhibition values of 72.97, 74.55, and 68.94%) and high antiproliferative activity (90.86%) in the HL-60 cell line. The in vitro sun protection factor (SPF) of the extracts and compound 4, with and without sunscreen, was determined by a spectrophotometric method. The ethanol extract exhibited the highest SPF (9.67) at a concentration of 0.100 mg/mL, while compound 4, isolated from this extract, showed a SPF of 13.79 at the same concentration. A relative increased efficacy of SPF was observed for the extracts and compound 4 when sunscreen was also used. Compound 4 has not been reported previously from any species within the genus Calea. Compounds 1–4 were obtained from this species for the first time.pt_BR
dc.identifier.citationSEREGETI, T. M. Q. et al. Antiproliferative and photoprotective activities of the extracts and compounds from Calea fruticosa. Brazilian Journal of Medical and Biological Research, v. 53, p. e9375-e9375, 2020. Disponível em: <https://www.scielo.br/j/bjmbr/a/9R5VyRbTJJLYBTCW3mthQYQ/?lang=en>. Acesso em: 10 jun. 2021.pt_BR
dc.identifier.doihttps://doi.org/10.1590/1414-431X20209375pt_BR
dc.identifier.issn1414-431X
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/14239
dc.language.isoen_USpt_BR
dc.rightsabertopt_BR
dc.rights.licenseThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: o PDF do artigo.pt_BR
dc.subjectFlavonept_BR
dc.subjectSesquiterpenic lactonept_BR
dc.subjectFlavonolpt_BR
dc.subjectGlucosylated coumarinpt_BR
dc.subjectSunscreen preparationpt_BR
dc.titleAntiproliferative and photoprotective activities of the extracts and compounds from Calea fruticosa.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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