Antidiabetic effect of Equisetum giganteum L. extract on alloxan-diabetic rabbit.

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dc.contributor.authorVieira, Geisla Teles
dc.contributor.authorOliveira, Tânia Toledo de
dc.contributor.authorCarneiro, Marco Antonio Alves
dc.contributor.authorCangussú, Silvia Dantas
dc.contributor.authorHumberto, Gabriel Almeida Paes
dc.contributor.authorTaylor, Jason Guy
dc.contributor.authorHumberto, Jorge Luiz
dc.date.accessioned2021-09-16T18:11:44Z
dc.date.available2021-09-16T18:11:44Z
dc.date.issued2020pt_BR
dc.description.abstractEthnopharmacological relevance: Equisetum giganteum has been traditionally used as an anti-diabetic herbal remedy to treat diabetes in the southern state of Rio Grande do Sul in Brazil. Aim of the study: Considering the ethonopharmacology and historical importance of E. giganteum, its potential antidiabetic effect was evaluated in alloxan induced diabetic rabbits. Material and methods: Samples of Equisetum giganteum were collected in the city of Ouro Preto, Minas Gerais, Brazil. Butanolic and aqueous extracts were prepared and subsequently evaluated for anti-diabetic properties in vivo using albino male rabbits. At the end of the treatment period, the animals were euthanized, and histopathological analysis were carried out. The following biochemical parameters were studied: glucose, triacylglycerol, cholesterol, albumin, creatinine, glycosylated hemoglobin and lipase. The phytochemical profile of the extracts was studied by liquid chromatography techniques coupled to a UV/VIS detector and highresolution mass spectrometry. Results: Both aqueous and butanolic extracts were capable of reducing significantly the levels of glucose, cholesterol and triacylglycerol and thus demonstrating their hypolipidemic and hypoglycemiant effects. Furthermore, the extracts prevented the occurrence of hepatic complications during treatment. The phytochemical profile of the extracts was investigated, and the natural products detected were in agreement with those that had been previously described in the literature. Conclusion: Based on the significant reductions in biochemical parameters and the histologic evidence for the absence of complications in the liver, pancreas of the treated animals, Equisetum giganteum can be a therapeutically relevant resource in the treatment of diabetes and hyperlipidemia.pt_BR
dc.identifier.citationVIEIRA, G. T. et al. Antidiabetic effect of Equisetum giganteum L. extract on alloxan-diabetic rabbit. Journal of Ethnopharmacology, v. 259, p. 112898, 2020. Disponível em: <https://www.sciencedirect.com/science/article/abs/pii/S037887411934855X>. Acesso em: 12 maio 2021.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.jep.2020.112898pt_BR
dc.identifier.issn0378-8741
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/13753
dc.identifier.uri2https://www.sciencedirect.com/science/article/abs/pii/S037887411934855Xpt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.titleAntidiabetic effect of Equisetum giganteum L. extract on alloxan-diabetic rabbit.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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