Antioxidant effects of oral Ang-(1-7) restore insulin pathway and RAS components ameliorating cardiometabolic disturbances in rats.

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dc.contributor.authorFigueiredo, Vivian Paulino
dc.contributor.authorBarbosa, Maria Andréa
dc.contributor.authorCastro, Uberdan Guilherme Mendes de
dc.contributor.authorZacarias, Aline Cruz
dc.contributor.authorBezerra, Frank Silva
dc.contributor.authorCota, Renata Guerra de Sá
dc.contributor.authorLima, Wanderson Geraldo de
dc.contributor.authorSantos, Robson Augusto Souza dos
dc.contributor.authorAlzamora, Andréia Carvalho
dc.date.accessioned2020-03-13T11:23:26Z
dc.date.available2020-03-13T11:23:26Z
dc.date.issued2019
dc.description.abstractIn prevention studies of metabolic syndrome (MetS), Ang-(1-7) has shown to improve the insulin signaling. We evaluated the HPβCD/Ang-(1-7) treatment on lipid metabolism, renin-angiotensin system (RAS) components, oxidative stress, and insulin pathway in the liver and gastrocnemius muscle and hepatic steatosis in rats with established MetS. After 7 weeks of high-fat (FAT) or control (CT) diets, rats were treated with cyclodextrin (HPβCD) or HPβCD/Ang-(1-7) in the last 6 weeks. FATHPβCD/ empty rats showed increased adiposity index and body mass, gene expression of ACE/ANG II/AT1R axis, and oxidative stress. These results were accompanied by imbalances in the insulin pathway, worsening of liver function, hyperglycemia, and dyslipidemia. Oral HPβCD/Ang-(1-7) treatment decreased ACE and AT1R, increased ACE2 gene expression. in the liver, and restored thiobarbituric acid reactive substances (TBARS), catalase (CAT), superoxide dismutase (SOD), insulin receptor substrate (Irs-1), glucose transporter type 4 (GLUT4), and serine/threonine kinase 2 (AKT-2) gene expression in the liver and gastrocnemius muscle improving hepatic function, cholesterol levels, and hyperglycemia in MetS rats. Overall, HPβCD/Ang-(1-7) treatment restored the RAS components, oxidative stress, and insulin signaling in the liver and gastrocnemius muscle contributing to the establishment of blood glucose and lipid homeostasis in MetS rats.pt_BR
dc.identifier.citationFIGUEIREDO, V. P. et al. Antioxidant effects of oral Ang-(1-7) restore insulin pathway and RAS components ameliorating cardiometabolic disturbances in rats. Oxidative Medicine and Cellular Longevity, v. 2019, p. 1-10, jul. 2019. Disponível em: <https://www.hindawi.com/journals/omcl/2019/5868935/>. Acesso em: 10 fev. 2020.pt_BR
dc.identifier.doihttps://doi.org/10.1155/2019/5868935pt_BR
dc.identifier.issn1942-0994
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/11994
dc.language.isoen_USpt_BR
dc.rightsabertopt_BR
dc.rights.licenseThis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: o próprio artigo.pt_BR
dc.titleAntioxidant effects of oral Ang-(1-7) restore insulin pathway and RAS components ameliorating cardiometabolic disturbances in rats.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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