A novel ruthenium(II) gallic acid complex disrupts the actin cytoskeleton and inhibits migration, invasion and adhesion of triple negative breast tumor cells.

Simple item page
dc.contributor.authorGraminha, Angelica Ellen
dc.contributor.authorAraujo Neto, João Honorato de
dc.contributor.authorCorrea, Rodrigo de Souza
dc.contributor.authorCominetti, Márcia Regina
dc.contributor.authorMenezes, Antônio Carlos Severo
dc.contributor.authorBatista, Alzir Azevedo
dc.date.accessioned2021-12-21T18:34:16Z
dc.date.available2021-12-21T18:34:16Z
dc.date.issued2021pt_BR
dc.description.abstractThis work describes the synthesis of three new ruthenium(II) complexes with gallic acid and derivatives of the general formula [Ru(L)(dppb)(bipy)]PF6, where L = gallate (GAC), benzoate (BAC), and esterified-gallate (EGA), bipy = 2,2’-bipyridine and dppb = 1,4-bis(diphenylphosphino)butane. The complexes were characterized by elemental analysis, molar conductivity, NMR, cyclic voltammetry, UV-vis and IR spectroscopy, and two of them by X-ray crystallography. Cell viability assays show promising results, indicating higher cytotoxicity of the complexes in MDA-MB-231 cells, a triple-negative breast cancer (TNBC) cell line, compared with the hormone-dependent MCF-7 cell line. Studies in vitro with the MDA-MB-231 cell line showed that only Ru(BAC) and Ru(GAC) interacted with BSA. Besides that, the Ru(GAC) complex, which has a polyphenolic acid, interacted in an apo-Tf structure and function dependent manner and it was able to inhibit the formation of reactive oxygen species. Ru(GAC) was able to cause damage to the cellular cytoskeleton leading to inhibition of some cellular processes of TNBC cells, such as invasion, migration, and adhesion.pt_BR
dc.identifier.citationGRAMINHA, A. E. et al. A novel ruthenium(II) gallic acid complex disrupts the actin cytoskeleton and inhibits migration, invasion and adhesion of triple negative breast tumor cells. Dalton Transactions v. 50, p. 323-335, 2021. Disponível em: <https://pubs.rsc.org/en/content/articlelanding/2021/DT/D0DT03490H>. Acesso em: 10 jun. 2021.pt_BR
dc.identifier.doihttps://doi.org/10.1039/D0DT03490Hpt_BR
dc.identifier.issn1477-9234
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/14280
dc.identifier.uri2https://pubs.rsc.org/en/content/articlelanding/2021/DT/D0DT03490Hpt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.titleA novel ruthenium(II) gallic acid complex disrupts the actin cytoskeleton and inhibits migration, invasion and adhesion of triple negative breast tumor cells.pt_BR
dc.typeArtigo publicado em periodicopt_BR
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
ARTIGO_NovelRutheniumGallic.pdf
Size:
2.94 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
DEQUI - Artigos publicados em periódicos