Coinfection with Toxoplasma gondii inhibits antigen-specific Th2 immune responses, tissue inflamation, and parasitism in BALB/c mice infected with Leishmania major.

Santiago, Helton da Costa; Oliveira, Milton Adriano Pelli de; Bambirra, Eduardo Alves; Faria, Ana Maria Caetano de; Afonso, Luís Carlos Crocco; Oliveira, Leda Quercia; Gazzinelli, Ricardo Tostes

Coinfection with Toxoplasma gondii inhibits antigen-specific Th2 immune responses, tissue inflamation, and parasitism in BALB/c mice infected with Leishmania major.

Date

1999

Authors

Santiago, Helton da Costa

Oliveira, Milton Adriano Pelli de

Bambirra, Eduardo Alves

Faria, Ana Maria Caetano de

Afonso, Luís Carlos Crocco

Oliveira, Leda Quercia

Gazzinelli, Ricardo Tostes

Abstract

Lesion size, cellular infiltration, and tissue parasitism in the footpads of BALB/c mice infected with Leishmania major were all dramatically inhibited during acute but not chronic infection with Toxoplasma gondii. Similarly, acute but not chronic toxoplasmosis at the time of infection with L. major had a strong inhibitory effect on development of acquired immune responses mediated by Th2 lymphocytes. In contrast, no m

Citation

SANTIAGO, H. da C. et al. Coinfection with Toxoplasma gondii inhibits antigen-specific Th2 immune responses, tissue inflamation, and parasitism in BALB/c mice infected with Leishmania major. Disponível em: <http://iai.asm.org/content/67/9/4939.full>. Acesso em: 19 fev. 2017.