Bracken (Pteridium aquilinum)-Induced DNA adducts in mouse tissues are different from the adduct induced by the activated form of the bracken carcinogen ptaquiloside.

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dc.contributor.authorFreitas, Renata Nascimento de
dc.contributor.authorO'Connor, P. J.
dc.contributor.authorPrakash, A. S.
dc.contributor.authorShahin, M.
dc.contributor.authorPovey, A. C.
dc.date.accessioned2015-03-20T17:17:39Z
dc.date.available2015-03-20T17:17:39Z
dc.date.issued2001
dc.description.abstractFollowing treatment with bracken fern (Pteridium aquilinum) extract and bracken spores a number of DNA adducts were detected by 32P-postlabeling. Three of these adducts have been described previously (Povey et al., Br. J. Cancer (1996) 74, 1342–1348) and in this study, using a slightly different protocol, four new adducts, with higher chromatographic mobility, were detected at levels ranging from 50 to 230% of those previously described. When DNA was treated in vitro with activated ptaquiloside (APT) and analysed by butanol extraction or nuclease P1 treatment, only one adduct was detected by 32P-postlabeling. This adduct was not present in the DNA from mice treated with bracken fern or spores, suggesting either that bracken contains genotoxins other than ptaquiloside or that the metabolism of ptaquiloside produces genotoxins not reflected by activated ptaquiloside. However, as the ATP-derived adduct has been detected previously in ileal DNA of bracken-fed calves, species-specific differences in the metabolism of bracken genotoxins may exist, thereby leading to differences in their biological outcomes.pt_BR
dc.identifier.citationFREITAS, R. N. de et al. Bracken (Pteridium aquilinum)-Induced DNA adducts in mouse tissues are different from the adduct induced by the activated form of the bracken carcinogen ptaquiloside. Biochemical and Biophysical Research Communications, v. 281, n. 2, p. 589-594, 2001. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0006291X01943888>. Acesso em: 26 jun. 2019.pt_BR
dc.identifier.doihttps://doi.org/10.1006/bbrc.2001.4388
dc.identifier.issn0006-291X
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/4682
dc.language.isoen_USpt_BR
dc.rights.licenseO periódico Biochemical and Biophysical Research Communications concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3556580402137.pt_BR
dc.subjectBracken fernpt_BR
dc.subjectPtaquilosidept_BR
dc.subjectAdductspt_BR
dc.subjectPostlabellingpt_BR
dc.titleBracken (Pteridium aquilinum)-Induced DNA adducts in mouse tissues are different from the adduct induced by the activated form of the bracken carcinogen ptaquiloside.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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