Antileishmanial activity of compounds produced by endophytic fungi derived from medicinal plant Vernonia polyanthes and their potential as source of bioactive substances.
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Date
2015
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Abstract
The purpose of this work was to evaluate the
antileishmanial activity of endophytic fungi isolated from
leaves of Vernonia polyanthes plant and their prospective
use in the discovery of bioactive compounds. Sixteen
endophytes were isolated by using potato dextrose agar
medium and submitted to cultivation in rice medium. The
fungal cultures were extracted with ethanol and used as
crude extracts for testing their antileishmanial activity. The
most active ethanol extract was obtained from P2-F3 strain,
which was identified as Cochliobolus sativus by ITS rRNA
gene sequence data. Followed by a bioassay-guided fractionation,
the cochlioquinone A, isocochlioquinone A and
anhydrocochlioquinone A compounds were isolated from
the crude extracts and demonstrated to inhibit the parasites.
From the present work, it is possible to conclude that
endophytic fungi derived from medicinal plant V. polyanthes
may be considered promising source for the discovery
of bioactive compounds.
Description
Keywords
Endophytes, Bioprospection, Leishmania amazonensis
Citation
NASCIMENTO, A. M. do et al. Antileishmanial activity of compounds produced by endophytic fungi derived from medicinal plant Vernonia polyanthes and their potential as source of bioactive substances. World Journal of Microbiology & Biotechnology, v. 31, p. 1793-1800, 2015. Disponível em: <https://link.springer.com/article/10.1007%2Fs11274-015-1932-0>. Acesso em: 05 ago. 2017.