Kinin receptors mediating the effect of bradykinin on gastric acid secretion.

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dc.contributor.authorAlzamora, Andréia Carvalho
dc.contributor.authorFerreira, Patrícia Maria
dc.contributor.authorOliveira, César Nonato de
dc.contributor.authorAlzamora, Fernando
dc.contributor.authorVieira, Maria Aparecida Ribeiro
dc.date.accessioned2012-07-19T13:59:19Z
dc.date.available2012-07-19T13:59:19Z
dc.date.issued1998
dc.description.abstractKinins, and bradykinin in particular, can affect electrolyte transport in different segments of the intestine, thus being able to stimulate chloride secretion. Since the stomach is the main chloride secretory unit in the gastrointestinal tract, we have investigated the effect of 2 8 2 6 bradykinin on acid secretion in the isolated frog (Rana catesbeiana) gastric mucosa. Bradykinin (2 3 10 to 2 3 10 M) and 9 2 9 2 7 des-Arg -bradykinin (2 3 10 to 23 10 M) were able to stimulate acid secretion in a dose-dependent manner. The bradykinin 2 79 2 85,872 7 (2 3 10 M) and des-Arg -bradykinin (2 3 10 M)-induced acid secretion was unaffected by Thi ,D -Phe -bradykinin (2 3 10 to 2 5 98 2 7 2 3 10 M), a B -kinin receptor antagonist. Interestingly, the B -kinin receptor antagonist, des-Arg -(Leu )-bradykinin (2 3 10 to 21 2 59 2 3 10 M) blocked both bradykinin- and des-Arg -bradykinin-stimulated acid secretion. Although the kininase I inhibitor, D -L -2 6 2 59 mercapto-methyl-3-guanidino-ethyl-propanoic acid (23 10 and 23 10 M) had no effect on des-Arg -bradykinin-induced acid 9 secretion, it inhibited the response to bradykinin. We conclude that bradykinin requires, at least in part, hydrolysis to des-Arg –bradykinin to increase gastric acid secretion and that its effect is mediated by B -kinin receptors.pt_BR
dc.identifier.citationALZAMORA, A. C. et al. Kinin receptors mediating the effect of bradykinin on gastric acid secretion. Reguladory Peptides, v. 73, n. 2, p. 113-117, fev. 1998. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0167011597010719>. Acesso em: 19 jul. 2012.pt_BR
dc.identifier.issn01670115
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/1174
dc.rights.licenseO periódico Peptides concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3285361278983.
dc.subjectKinin antagonistpt_BR
dc.subjectKinin analoguespt_BR
dc.subjectGastric mucosapt_BR
dc.subjectCarboxipeptidase inhibitionpt_BR
dc.titleKinin receptors mediating the effect of bradykinin on gastric acid secretion.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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