Ghrelin plasma levels, gastric ghrelin cell density and bone mineral density in women with rheumatoid arthritis.
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Date
2017
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Abstract
Generalized bone loss can be considered an extra-articular manifestation of rheumatoid arthritis (RA) that may lead to the
occurrence of fractures, resulting in decreased quality of life and increased healthcare costs. The peptide ghrelin has demonstrated
to positively affect osteoblasts in vitro and has anti-inflammatory actions, but the studies that correlate ghrelin
plasma levels and RA have contradictory results. We aimed to evaluate the correlation between total ghrelin plasma levels,
density of ghrelin-immunoreactive cells in the gastric mucosa, and bone mineral density (BMD) in twenty adult women with
established RA with 6 months or more of symptoms (mean age of 52.70±11.40 years). Patients with RA presented higher
ghrelin-immunoreactive cells density in gastric mucosa (P=0.008) compared with healthy females. There was a positive
relationship between femoral neck BMD and gastric ghrelin cell density (P=0.007). However, these same patients presented
a negative correlation between plasma ghrelin levels and total femoral BMD (P=0.03). The present results indicate that
ghrelin may be involved in bone metabolism of patients with RA. However, the higher density of ghrelin-producing cells in the
gastric mucosa of these patients does not seem to induce a corresponding elevation in the plasma levels of this peptide.
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Keywords
Gastric mucosa, Bone metabolism, Osteoporosis, Rheumatoid arthritis
Citation
MAKSUD, F. A. N. et al. Ghrelin plasma levels, gastric ghrelin cell density and bone mineral density in women with rheumatoid arthritis. Brazilian Journal Of Medical And Biological Research, v. 50, p. 1-6, 2017. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000600704&lng=en&nrm=iso&tlng=en>. Acesso em: 29 ago. 2017.