Second harmonic generation imaging of the collagen architecture in prostate cancer tissue.

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dc.contributor.authorGarcia, Aloísio Miguel
dc.contributor.authorMagalhães, Felipe Lima
dc.contributor.authorSoares, Jaqueline dos Santos
dc.contributor.authorPaulino Junior, Eduardo
dc.contributor.authorLima, Mario Felix Richard de
dc.contributor.authorLewer, Marcelo Henrique Mamede
dc.contributor.authorPaula, Ana Maria de
dc.date.accessioned2018-10-29T15:46:30Z
dc.date.available2018-10-29T15:46:30Z
dc.date.issued2018
dc.description.abstractOptical microscopy has been one of the most important tools for visualizing biological samples since the seventeenth century. Recently, with the advances in femtosecond laser technology, all the nonlinear optical processes have now been included as optical microscopy methods, and second harmonic generation (SHG) microscopy has emerged as a powerful new optical imaging tool with applications in medicine and biology. Here we use SHG microscopy to obtain images of 76 prostate biopsies on histological slides. Multiple samples from the excised prostates of patients who underwent a radical prostatectomy were evaluated. The samples were collected from prostate positions as in needle biopsy procedures. The results show the collagen fiber architecture among malignant acini, and analysis of the fiber orientation in the images reveals that the collagen fibers become more aligned at higher malignancy grades. Furthermore, we find that the degree of fiber alignment correlates directly with the Gleason patterns.pt_BR
dc.identifier.citationGARCIA, A. M. et al. Second harmonic generation imaging of the collagen architecture in prostate cancer tissue. Biomedical Physics & Engineering Express, v. 4, n. 2, p. 1-12, fev. 2018. Disponível em: <http://iopscience.iop.org/article/10.1088/2057-1976/aaa379>. Acesso em: 16 jun. 2018.pt_BR
dc.identifier.issn20571976
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/10475
dc.identifier.uri2http://iopscience.iop.org/article/10.1088/2057-1976/aaa379pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectNonlinear microscopypt_BR
dc.subjectMedical and biological imagingpt_BR
dc.titleSecond harmonic generation imaging of the collagen architecture in prostate cancer tissue.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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