Raman spectroscopy with a 1064-nm wavelength laser as a potential molecular tool for prostate cancer diagnosis : a pilot study.
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Date
2018
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Abstract
Raman spectroscopy is widely used to investigate the structure and property of the molecules from
their vibrational transitions and may allow for the diagnosis of cancer in a fast, objective, and nondestructive
manner. This experimental study aims to propose the use of the 1064-nm wavelength laser in a Raman spectroscopy
and to evaluate its discrimination capability in prostate cancer diagnosis. Seventy-four spectra from
patients who underwent radical prostatectomy were evaluated. The acquired signals were filtered, normalized,
and corrected for possible oscillations in the laser intensity and fluorescence effects. Wilcoxon tests revealed
significant differences between the benign and malign samples associated with the deformation vibration
characteristic of nucleic acids, proteins, and lipids. A classifier based on support vector machines was able to
predict the Gleason scores of the samples with 95% of accuracy, opening a perspective for the use of the
1064-nm excitatory wavelength in prostatic cancer diagnosis.
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Fluorescence
Citation
MAGALHÃES, F. L. et al. Raman spectroscopy with a 1064-nm wavelength laser as a potential molecular tool for prostate cancer diagnosis : a pilot study. Journal of Biomedical Optics, v. 23, n. 12, p. 121613, 2018. Disponível em: <https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-23/issue-12/121613/Raman-spectroscopy-with-a-1064-nm-wavelength-laser-as-a/10.1117/1.JBO.23.12.121613.full?SSO=1>. Acesso em: 19 mar. 2019.