Clinical and laboratory status of patients with chronic Chagas disease living in a vector controlled area in Minas Gerais, Brazil, before and nine years after aetiological treatment.

Lana, Marta deLopes, Leonardo de AraújoMartins, Helen RodriguesBahia, Maria TerezinhaAssis, Girley Francisco Machado deWendling, Ana Paula BarbosaMartins Filho, Olindo AssisMontoya, Roberto AraújoDias, João Carlos PintoViñas, Pedro AlbajarCoura, José Rodrigues2014-11-192014-11-192009LANA, M. et al. Clinical and laboratory status of patients with chronic Chagas disease living in a vector-controlled area in Minas Gerais, Brazil, before and nine years after aetiological treatment. Memórias do Instituto Oswaldo Cruz, v. 104, p. 1139-1147, 2009. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000800011&lng=en&nrm=iso&tlng=en>. Acesso em: 28 ago. 2014.0074-0276http://www.repositorio.ufop.br/handle/123456789/3970Twenty-eight Chagas disease patients (CD), 22 with the indeterminate clinical form (IND) and six with the cardiac or digestive form (CARD/DIG), were treated with benznidazole and underwent clinical and laboratorial analysis before (IND and CARD/DIG) and nine years after [patients after treatment (CDt), patients with the indeterminate clinical form at treatment onset (INDt) and with the cardiac or digestive form at treatment onset (CARD/DIGt)] treatment. The data demonstrate that 82.1% of CDt patients (23/28) remained clinically stable and 95.4% of the INDt (21/22) and 33.3% of the CARD/DIGt (2/6) patients showed unaltered physical and laboratorial examinations. The clinical evolution rate was 2%/year and was especially low in INDt patients (0.5%/year) relative to CARD/DIGt patients (7.4%/year). Positive haemoculture in treated patients was observed in 7.1% of the cases. None of the INDt (0/21) and 33.3% of the CARD/DIGt (2/6) patients displayed positive cultures. The PCR presented a positive rate significantly higher (85.2%, 23/27) than haemoculture and two samples from the same patient revealed the same result 57.7% of the patients. Conventional serology-ELISA on 16 paired samples remained positive in all individuals. Semi-quantitative ELISA highlighted significant decreases in reactivity, particularly in INDt relative to IND. Non-conventional serology- FC-ALTA-IgG, after treatment, showed positive results in all sera and 22 paired samples examined at seven and nine years after treatment, demonstrated significantly lower reactivity, particularly in INDt patients. This study was retrospective in nature, had a low number of samples and lacked an intrinsic control group, but the data corroborate other results found in the literature. The data also demonstrate that, even though a cure has not been detected in the none-treated patients, the benefits for clinical evolution were selectively observed in the group of INDt patients and did not occur for CARD/DIGt patients.en-USChagas diseaseAetiological treatmentBenznidazoleClinical evolutionClinical-laboratorial evaluationClinical and laboratory status of patients with chronic Chagas disease living in a vector controlled area in Minas Gerais, Brazil, before and nine years after aetiological treatment.Artigo publicado em periodicoO periódico Memórias do Instituto Oswaldo Cruz permite que o Repositório Institucional da Universidade Federal de Ouro Preto (UFOP) deposite uma cópia eletrônica dos artigos publicados por esse periódico em que ao menos um dos autores faça parte da comunidade cientifica da UFOP. Fonte: Licença concedida mediante prenchimento de formulário enviado no dia 12 dez. 2013.http://dx.doi.org/10.1590/S0074-02762009000800011